Faraci, Frank M., and Donald D. Heistad. Regulation of the Cerebral Circulation: Role of
Endothelium and Potassium Channels. Physiol. Rev. 78: 53–97, 1998.—Several new …

The cerebrovascular endothelium exerts a profound influence on cerebral vessels and
cerebral blood flow. This review summarizes current knowledge of various dilator and …

Mechanisms that regulate the cerebral circulation have been intensively investigated in
recent years. The role of several vasodilator mechanisms has been examined in the …

The tight coupling between increased neuronal activity and local cerebral blood flow, known
as functional hyperemia, is essential for normal brain function. However, its cellular and …

Background and Purpose Endothelin 1 (ET-1), a highly potent endogenous vasoactive
peptide, exerts a sustained vasoconstrictive effect on cerebral vessels. Elevation of ET-1 in …

In brain disorders, reactive astrocytes, which are characterized by hypertrophy of the cell
body and proliferative properties, are commonly observed. As reactive astrocytes are …

Cerebrovascular insults are a leading cause of brain injury in premature infants, contributing
to the high prevalence of motor, cognitive, and behavioral deficits. Understanding the …

Traumatic brain injury (TBI) is induced by the immediate physical disruption of brain tissue.
TBI causes disruption of the blood–brain barrier (BBB) and brain edema. In the …

Endothelins (ETs) are potent vasoconstrictor and may play a role in the pathophysiology of
several cardiovascular diseases. Endothelin-mediated vasoconstriction may enhance …

1 Endothelin (ET) has been implicated in cerebrovasospasm for example, following
subarachnoid haemorrhage, and blocking the interaction of ET with its receptors on cerebral …