An evolutionary and physiological perspective on cell-substrate adhesion machinery for cell migration

JC Fierro Morales, Q Xue… - Frontiers in Cell and …, 2022 - frontiersin.org
Cell-substrate adhesion is a critical aspect of many forms of cell migration. Cell adhesion to
an extracellular matrix (ECM) generates traction forces necessary for efficient migration. One …

Cell shape and durotaxis explained from cell-extracellular matrix forces and focal adhesion dynamics

EG Rens, RMH Merks - Iscience, 2020 - cell.com
Many cells are small and rounded on soft extracellular matrices (ECM), elongated on stiffer
ECMs, and flattened on hard ECMs. Cells also migrate up stiffness gradients (durotaxis) …

A computational study of amoeboid motility in 3D: the role of extracellular matrix geometry, cell deformability, and cell–matrix adhesion

EJ Campbell, P Bagchi - Biomechanics and modeling in mechanobiology, 2021 - Springer
Amoeboid cells often migrate using pseudopods, which are membrane protrusions that
grow, bifurcate, and retract dynamically, resulting in a net cell displacement. Many cells …

Coupling Polar Adhesion with Traction, Spring, and Torque Forces Allows High-Speed Helical Migration of the Protozoan Parasite Toxoplasma

G Pavlou, B Touquet, L Vigetti, P Renesto… - ACS …, 2020 - ACS Publications
Among the eukaryotic cells that navigate through fully developed metazoan tissues,
protozoans from the Apicomplexa phylum have evolved motile developmental stages that …

[HTML][HTML] 力敏感受体介导细胞功能调控的力学生物学研究

张欢, 赵国清, 冯锦腾, 林敏 - 力学进展, 2023 - lxjz.cstam.org.cn
细胞膜是细胞与外部环境进行物质与能量交换的界面, 是调节细胞正常生命活动的重要结构基础
. 细胞膜上力敏感受体可通过力学作用方式参与并影响细胞的力信号转导等功能 …

Computational modelling of cell motility modes emerging from cell-matrix adhesion dynamics

L van Steijn, IMN Wortel, C Sire, L Dupré… - PLoS computational …, 2022 - journals.plos.org
Lymphocytes have been described to perform different motility patterns such as Brownian
random walks, persistent random walks, and Lévy walks. Depending on the conditions, such …

Integrative experimental/computational approach establishes active cellular protrusion as the primary driving force of phagocytic spreading by immune cells

EA Francis, V Heinrich - PLOS Computational Biology, 2022 - journals.plos.org
The dynamic interplay between cell adhesion and protrusion is a critical determinant of
many forms of cell motility. When modeling cell spreading on adhesive surfaces, traditional …

Cytoplasmic flow and mixing due to deformation of motile cells

EF Koslover, CK Chan, JA Theriot - Biophysical journal, 2017 - cell.com
The cytoplasm of a living cell is a dynamic environment through which intracellular
components must move and mix. In motile, rapidly deforming cells such as human …

[HTML][HTML] Membrane tension can enhance adaptation to maintain polarity of migrating cells

C Zmurchok, J Collette, V Rajagopal, WR Holmes - Biophysical Journal, 2020 - cell.com
Migratory cells are known to adapt to environments that contain wide-ranging levels of
chemoattractant. Although biochemical models of adaptation have been previously …

Modeling cell protrusion predicts how myosin II and actin turnover affect adhesion-based signaling

A Chandra, MT Butler, JE Bear, JM Haugh - Biophysical journal, 2022 - cell.com
Orchestration of cell migration is essential for development, tissue regeneration, and the
immune response. This dynamic process integrates adhesion, signaling, and cytoskeletal …