The phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of
rapamycin (mTOR)-dependent pathway is one of the most integral pathways linked to cell …

Fluorine-19 (19F)-based contrast agents for magnetic resonance imaging stand to
revolutionize imaging-based research and clinical trials in several fields of medical …

Magnetic resonance imaging (MRI) is a potentially ideal imaging modality for noninvasive,
nonionizing, and longitudinal assessment of disease. Hyperpolarized (HP) agents have …

Purpose To demonstrate the feasibility of quantitative and comprehensive global evaluation
of pulmonary function and microstructural changes in rats with radiation‐induced lung injury …

Rationale and Objectives Hyperpolarized xenon-129 magnetic resonance (MR) provides
sensitive tools that may detect early stages of lung disease in smokers before it has …

Perfusion measurements can provide vital information about the homeostasis of an organ
and can therefore be used as biomarkers to diagnose a variety of cardiovascular, renal, and …

Pulmonary diseases usually result in changes of the blood‐gas exchange function in the
early stages. Gas exchange across the respiratory membrane and gas diffusion in the …

Purpose To investigate the degree to which lung ventilation and gas exchange are
regionally correlated, using the emerging technology of hyperpolarized (HP)-129 Xe …

Purpose To implement and optimize a single‐shot spiral encoding strategy for rapid 2D
IDEAL projection imaging of hyperpolarized (Hp) 129Xe in the gas phase, and in the …

Purpose To map physiological gas exchange parameters using dissolved hyperpolarized
(HP) 129Xe in a rat model of regional radiation‐induced lung injury (RILI) with spiral‐IDEAL …