Primarily used in the treatment of intermittent claudication, cilostazol is a 2-oxyquinolone
derivative that works through the inhibition of phosphodiesterase III and related increases in …

Simple Summary The primary characteristics of cancer cachexia are weakness, weight loss,
atrophy, fat reduction, and systemic inflammation. Cachexia is strongly associated with …

Carvacrol is a natural phenolic monoterpenoid, and cilostazol is a selective
phosphodiesterase-3 inhibitor with antioxidant, anti-inflammatory and antiapoptotic effects …

The study was conducted to determine whether corosolic acid could protect the myocardium
of diabetic rats from damage caused by isoproterenol (ISO) and, if so, how peroxisome …

Atherosclerotic cardiovascular disease (ASCVD) stands as the leading global cause of
mortality. Addressing this vital and pervasive condition requires a multifaceted approach, in …

Ischemia-reperfusion injury (IRI) is a complex pathophysiological process that is often
characterized as a blood circulation disorder caused due to various factors (such as …

Background: the nephrotoxicity of methotrexate (MTX) is observed in high-dose therapy.
Moreover, low-dose MTX therapy for rheumatic diseases is debatable and claimed to cause …

Kidney injury from chemotherapy is one of the worsening problems associated with
methotrexate (MTX) use. This work aims to examine the nephroprotective effects of …

The ongoing loss of skeletal muscle is a central event of cancer cachexia, and its
consequences include adverse effects on patient's quality of life and survival. Alpinetin (Alp) …

Methotrexate (MTX)-induced gastrointestinal mucositis is a common adverse effect
characterized by redox imbalance and overproduction of inflammatory mediators that …