Chemical approaches to cryopreservation

KA Murray, MI Gibson - Nature Reviews Chemistry, 2022 - nature.com
Cryopreservation of cells and biologics underpins all biomedical research from routine
sample storage to emerging cell-based therapies, as well as ensuring cell banks provide …

Ice inhibition for cryopreservation: materials, strategies, and challenges

T Chang, G Zhao - Advanced Science, 2021 - Wiley Online Library
Cryopreservation technology has developed into a fundamental and important supporting
method for biomedical applications such as cell‐based therapeutics, tissue engineering …

Intracellular delivery by membrane disruption: mechanisms, strategies, and concepts

MP Stewart, R Langer, KF Jensen - Chemical reviews, 2018 - ACS Publications
Intracellular delivery is a key step in biological research and has enabled decades of
biomedical discoveries. It is also becoming increasingly important in industrial and medical …

Cryoprotectant toxicity: facts, issues, and questions

BP Best - Rejuvenation research, 2015 - liebertpub.com
High levels of penetrating cryoprotectants (CPAs) can eliminate ice formation during
cryopreservation of cells, tissues, and organs to cryogenic temperatures. But CPAs become …

Arbuscular mycorrhizal fungal responses to abiotic stresses: a review

I Lenoir, J Fontaine, ALH Sahraoui - Phytochemistry, 2016 - Elsevier
The majority of plants live in close collaboration with a diversity of soil organisms among
which arbuscular mycorrhizal fungi (AMF) play an essential role. Mycorrhizal symbioses …

Lipid and Carbohydrate Metabolism in Caenorhabditis elegans

JL Watts, M Ristow - Genetics, 2017 - academic.oup.com
Lipid and carbohydrate metabolism are highly conserved processes that affect nearly all
aspects of organismal biology. Caenorhabditis elegans eat bacteria, which consist of lipids …

A reversibly gated protein-transporting membrane channel made of DNA

S Dey, A Dorey, L Abraham, Y Xing, I Zhang… - Nature …, 2022 - nature.com
Controlled transport of biomolecules across lipid bilayer membranes is of profound
significance in biological processes. In cells, cargo exchange is mediated by dedicated …

To protect and to preserve: novel preservation strategies for extracellular vesicles

GD Kusuma, M Barabadi, JL Tan… - Frontiers in …, 2018 - frontiersin.org
Extracellular vesicles (EVs)-based therapeutics are based on the premise that EVs shed by
stem cells exert similar therapeutic effects and these have been proposed as an alternative …

Effect of trehalose on protein structure

NK Jain, I Roy - Protein Science, 2009 - Wiley Online Library
Trehalose is a ubiquitous molecule that occurs in lower and higher life forms but not in
mammals. Till about 40 years ago, trehalose was visualized as a storage molecule, aiding …

Trehalose: current use and future applications

S Ohtake, YJ Wang - Journal of pharmaceutical sciences, 2011 - Elsevier
Trehalose, a disaccharide of glucose, has been reported to accumulate in many organisms
that can withstand extended periods of inanimation. Since this discovery, the properties of …