Background: Alzheimer's disease (AD) is a neurodegenerative impairment mainly
recognized by memory loss and cognitive deficits. However, the current therapies against …

Cognitive control decline is a major manifestation of brain aging that severely impairs the
goal-directed abilities of older adults. Magnetic resonance imaging evidence suggests that …

A primary challenge to the data-driven analysis is the balance between poor generalizability
of population-based research and characterizing more subject-, study-and population …

The neural activity of human brain changes in healthy individuals during aging. The most
frequent variation in patterns of neural activity are a shift from posterior to anterior areas and …

Variability drives the organization and behavior of complex systems, including the human
brain. Understanding the variability of brain signals is thus necessary to broaden our …

Previous studies have demonstrated that the brain functional modular organization, which is
a fundamental feature of the human brain, would change along the adult lifespan. However …

Understanding the common topological characteristics of the human brain network across a
population is central to understanding brain functions. The abstraction of human …

Working memory is critical to higher-order executive processes and declines throughout the
adult lifespan. However, our understanding of the neural mechanisms underlying this …

Cognitive flexibility, the ability to switch between mental processes to generate appropriate
behavioral responses, is reduced with typical aging. Previous studies have found that age …

Abstract Machine learning algorithms are increasingly being utilized to identify brain
connectivity biomarkers linked to behavioral and clinical outcomes. However, research often …