Calcium sensors in neuronal function and dysfunction

RD Burgoyne, N Helassa… - Cold Spring Harbor …, 2019 - cshperspectives.cshlp.org
Calcium signaling in neurons as in other cell types can lead to varied changes in cellular
function. Neuronal Ca2+ signaling processes have also become adapted to modulate the …

The diversity of calcium sensor proteins in the regulation of neuronal function

HV McCue, LP Haynes… - Cold Spring Harbor …, 2010 - cshperspectives.cshlp.org
Calcium signaling in neurons as in other cell types mediates changes in gene expression,
cell growth, development, survival, and cell death. However, neuronal Ca2+ signaling …

Restoring Oat Nanoparticles Mediated Brain Memory Function of Mice Fed Alcohol by Sorting Inflammatory Dectin‐1 Complex Into Microglial Exosomes

F Xu, J Mu, Y Teng, X Zhang, K Sundaram… - Small, 2022 - Wiley Online Library
Microglia modulate pro‐inflammatory and neurotoxic activities. Edible plant‐derived factors
improve brain function. Current knowledge of the molecular interactions between edible …

Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1

JS Iwig, Y Vercoulen, R Das, T Barros, A Limnander… - Elife, 2013 - elifesciences.org
RasGRP1 and SOS are Ras-specific nucleotide exchange factors that have distinct roles in
lymphocyte development. RasGRP1 is important in some cancers and autoimmune …

On the mechanism of calcium‐dependent activation of NADPH oxidase 5 (NOX5)

E Millana Fañanás, S Todesca, A Sicorello… - The FEBS …, 2020 - Wiley Online Library
It is now accepted that reactive oxygen species (ROS) are not only dangerous oxidative
agents but also chemical mediators of the redox cell signaling and innate immune response …

Survey of the year 2008: applications of isothermal titration calorimetry

RJ Falconer, A Penkova, I Jelesarov… - Journal of molecular …, 2010 - Wiley Online Library
Isothermal titration calorimetry (ITC) is a fast, accurate and label‐free method for measuring
the thermodynamics and binding affinities of molecular associations in solution. Because the …

Direct single-molecule observation of calcium-dependent misfolding in human neuronal calcium sensor-1

PO Heidarsson, MM Naqvi, MR Otazo… - Proceedings of the …, 2014 - National Acad Sciences
Neurodegenerative disorders are strongly linked to protein misfolding, and crucial to their
explication is a detailed understanding of the underlying structural rearrangements and …

Calneurons provide a calcium threshold for trans-Golgi network to plasma membrane trafficking

M Mikhaylova, PP Reddy, T Munsch… - Proceedings of the …, 2009 - National Acad Sciences
Phosphatidylinositol 4-OH kinase IIIβ (PI-4Kβ) is involved in the regulated local synthesis of
phospholipids that are crucial for trans-Golgi network (TGN)-to-plasma membrane trafficking …

Structural and functional deficits in a neuronal calcium sensor-1 mutant identified in a case of autistic spectrum disorder

MTW Handley, LY Lian, LP Haynes, RD Burgoyne - PloS one, 2010 - journals.plos.org
Neuronal calcium sensor-1 (NCS-1) is a Ca2+ sensor protein that has been implicated in the
regulation of various aspects of neuronal development and neurotransmission. It exerts its …

Functional status of neuronal calcium sensor-1 is modulated by zinc binding

PO Tsvetkov, AY Roman, VE Baksheeva… - Frontiers in Molecular …, 2018 - frontiersin.org
Neuronal calcium sensor-1 (NCS-1) protein is abundantly expressed in the central nervous
system and retinal neurons, where it regulates many vital processes such as synaptic …