Intranasal delivery has shown to circumvent blood-brain-barrier (BBB) and deliver the drugs
into the CNS at a higher rate and extent than other conventional routes. The mechanism of …

The treatment of various central nervous system (CNS) diseases has been challenging,
despite the rapid development of several novel treatment approaches. The blood–brain …

Nose-to-brain drug delivery has recently attracted enormous attention as an alternative to
other delivery routes, including the most popular oral one. Due to the unique anatomical …

Nasal drug delivery is advantageous when compared with other routes of drug delivery as it
avoids the hepatic first-pass effect, blood–brain barrier penetration, and compliance issues …

In order to investigate the possible role of butter oil (BO) and omega-3 fatty acids–rich fish oil
(O3FO) in the delivery of donepezil hydrochloride microemulsion (DH-ME) to the brain via …

Nanotechnology has proved its tremendous worth in the field of drug delivery and targeting.
Nano formulations have improved the safety and efficacy of various conventional drugs …

Background Tight junctions and efflux transporters are two chief bodyguards of the blood–
brain barrier that protect the brain and create challenges for the treatment of neurological …

The aim of the study was to formulate a microemulsion (ME) using chitosan (CH) and the
butter oil (BO) as a permeation enhancer for targeting drug to the posterior segment of the …

This study aimed to formulate and statistically optimize glycerosomal formulations of
Quetiapine fumarate (QTF) to increase its oral bioavailability and enhance its brain delivery …

Since the discovery of fatty acids, a niche has been carved for their vital role as adjuvants in
drug delivery and as treatment for various diseases. The literature has repeatedly described …