• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

MicroRNAs (miRNAs) are small regulatory molecules post-transcriptionally suppressing
mRNA activity. Many miRNAs in various organisms have been cloned but many unknown …

Background: Pulsed field ablation uses electrical pulses to cause nonthermal irreversible
electroporation and induce cardiac cell death. Pulsed field ablation may have effectiveness …

Importance Pulmonary vein isolation (PVI) alone is less effective in patients with persistent
atrial fibrillation (AF) compared with paroxysmal AF. The left atrial posterior wall may …

Importance Ablation of persistent atrial fibrillation (AF) remains a challenge. Left atrial
fibrosis plays an important role in the pathophysiology of AF and has been associated with …

Abstract The Canadian Cardiovascular Society (CCS) atrial fibrillation (AF) guidelines
program was developed to aid clinicians in the management of these complex patients, as …

Pacemaker treatment for bradyarrhythmia was first approved for national health insurance
coverage in Japan in 1974, and its use rapidly became widespread thereafter …

Background Clinically effective ablation approaches for patients with persistent atrial
fibrillation (AF) are still being debated. So far, ablation targets and strategies beyond …

Background Paroxysmal and permanent atrial fibrillation (AF) are common in heart failure
with preserved ejection fraction (HFpEF). Objectives This study sought to determine the …

Importance Catheter ablation of persistent atrial fibrillation (AF) has limited success.
Procedural strategies beyond pulmonary vein isolation have failed to consistently improve …