The immunology of sepsis
T van der Poll, M Shankar-Hari, WJ Wiersinga - Immunity, 2021 - cell.com
Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host
response to an infection. This recently implemented definition does not capture the …
response to an infection. This recently implemented definition does not capture the …
2023 update on sepsis and septic shock in adult patients: management in the emergency department
Background: Sepsis/septic shock is a life-threatening and time-dependent condition that
requires timely management to reduce mortality. This review aims to update physicians with …
requires timely management to reduce mortality. This review aims to update physicians with …
Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021
Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to
infection (1). Sepsis and septic shock are major healthcare problems, impacting millions of …
infection (1). Sepsis and septic shock are major healthcare problems, impacting millions of …
Longitudinal genomic surveillance of carriage and transmission of Clostridioides difficile in an intensive care unit
Despite enhanced infection prevention efforts, Clostridioides difficile remains the leading
cause of healthcare-associated infections in the United States. Current prevention strategies …
cause of healthcare-associated infections in the United States. Current prevention strategies …
Sepsis therapies: learning from 30 years of failure of translational research to propose new leads
Sepsis has been identified by the World Health Organization (WHO) as a global health
priority. There has been a tremendous effort to decipher underlying mechanisms …
priority. There has been a tremendous effort to decipher underlying mechanisms …
The gut microbiome's role in the development, maintenance, and outcomes of sepsis
MW Adelman, MH Woodworth, C Langelier, LM Busch… - Critical care, 2020 - Springer
The gut microbiome regulates a number of homeostatic mechanisms in the healthy host
including immune function and gut barrier protection. Loss of normal gut microbial structure …
including immune function and gut barrier protection. Loss of normal gut microbial structure …
[HTML][HTML] In critically ill patients, anti-anaerobic antibiotics increase risk of adverse clinical outcomes
R Chanderraj, JM Baker, SG Kay… - European …, 2023 - Eur Respiratory Soc
Background Critically ill patients routinely receive antibiotics with activity against anaerobic
gut bacteria. However, in other disease states and animal models, gut anaerobes are …
gut bacteria. However, in other disease states and animal models, gut anaerobes are …
Gut-liver crosstalk in sepsis-induced liver injury
J Sun, J Zhang, X Wang, F Ji, C Ronco, J Tian, Y Yin - Critical Care, 2020 - Springer
Sepsis is characterized by a dysregulated immune response to infection leading to life-
threatening organ dysfunction. Sepsis-induced liver injury is recognized as a powerful …
threatening organ dysfunction. Sepsis-induced liver injury is recognized as a powerful …
Challenge to the intestinal mucosa during sepsis
F Haussner, S Chakraborty, R Halbgebauer… - Frontiers in …, 2019 - frontiersin.org
Sepsis is a complex of life-threating organ dysfunction in critically ill patients, with a primary
infectious cause or through secondary infection of damaged tissues. The systemic …
infectious cause or through secondary infection of damaged tissues. The systemic …
Therapeutic potential of the gut microbiota in the prevention and treatment of sepsis
Alongside advances in understanding the pathophysiology of sepsis, there have been
tremendous strides in understanding the pervasive role of the gut microbiota in systemic …
tremendous strides in understanding the pervasive role of the gut microbiota in systemic …