The isolation of phlorizin from the bark of an apple tree in 1835 led to a flurry of research on
its inhibitory effect on glucose transporters in the intestine and kidney. Using phlorizin as a …

Reactive oxygen species (ROS) play a crucial role in cell survival regulation, and its low
levels may act as indicators to encourage cellular proliferation. In contrast, elevated levels of …

Reducing fat deposits in hepatocytes is a direct treatment for nonalcoholic fatty liver disease
(NAFLD) and the fatty acid metabolic processes mediated by fatty acid β-oxidation are …

The importance of gut-liver axis in the pathophysiology of metabolic dysfunction-associated
fatty liver disease (MAFLD) is being investigated more closely in recent times. However, the …

Obesity is an epidemic and a growing public health concern worldwide. It is one of the
significant risk factors for developing chronic kidney disease. In the present study, we …

Phloretin (PHL) is a dihydrochalcone flavonoid isolated from the peel and root bark of
apples, strawberries, and other plants with antioxidative characteristic. In this study, we …

The current study sought to evaluate the acute effects of phloretin (PH) on metabolic
pathways involved in the maintenance of glycemia, specifically gluconeogenesis and …

Abstract Head and neck Squamous Cell Carcinoma (HNSCC) is a growing concern
worldwide and MAPKAPK2/MK2 (Mitogen-Activated Protein Kinase Activated Protein Kinase …

Liver fibrosis is a chronic liver disease characterized by extracellular matrix protein
accumulation, potentially leading to cirrhosis or hepatocellular carcinoma. Liver cell …

Aims The rising prevalence of type 2 diabetes mellitus (T2DM) and accompanying insulin
resistance is alarming globally. Natural and synthetic agonists of PPARγ are potentially …