Innovative therapeutic approaches for Duchenne muscular dystrophy

F Fortunato, R Rossi, MS Falzarano… - Journal of Clinical …, 2021 - mdpi.com
Duchenne muscular dystrophy (DMD) is the most common childhood muscular dystrophy
affecting~ 1: 5000 live male births. Following the identification of pathogenic variations in the …

Combined therapies for Duchenne muscular dystrophy to optimize treatment efficacy

G Cordova, E Negroni, C Cabello-Verrugio… - Frontiers in …, 2018 - frontiersin.org
Duchene Muscular Dystrophy (DMD) is the most frequent muscular dystrophy and one of the
most severe due to the absence of the dystrophin protein. Typical pathological features …

Targeting RAGE prevents muscle wasting and prolongs survival in cancer cachexia

S Chiappalupi, G Sorci, A Vukasinovic… - Journal of cachexia …, 2020 - Wiley Online Library
Background Cachexia, a multifactorial syndrome affecting more than 50% of patients with
advanced cancer and responsible for~ 20% of cancer‐associated deaths, is still a poorly …

MG53 attenuates lipopolysaccharide-induced neurotoxicity and neuroinflammation via inhibiting TLR4/NF-κB pathway in vitro and in vivo

F Guan, X Zhou, P Li, Y Wang, M Liu, F Li, Y Cui… - Progress in Neuro …, 2019 - Elsevier
Neuroinflammation plays important roles in the pathogenesis and development of
neurodegenerative disorders. Lipopolysaccharide (LPS) induces neuroinflammation and …

Functions of vertebrate ferlins

AV Bulankina, S Thoms - Cells, 2020 - mdpi.com
Ferlins are multiple-C2-domain proteins involved in Ca2+-triggered membrane dynamics
within the secretory, endocytic and lysosomal pathways. In bony vertebrates there are six …

Silver nanoparticles induce cell death of colon cancer cells through impairing cytoskeleton and membrane nanostructure

H Xiao, Y Chen, M Alnaggar - Micron, 2019 - Elsevier
Globally, colon cancer is a predominant cause of increased morbidity and mortality annually;
therefore, in addition to traditional treatments, new protocols are under continuous …

Actin cytoskeletal dynamics in single-cell wound repair

ML Ebstrup, C Dias, ASB Heitmann, SL Sønder… - International Journal of …, 2021 - mdpi.com
The plasma membrane protects the eukaryotic cell from its surroundings and is essential for
cell viability; thus, it is crucial that membrane disruptions are repaired quickly to prevent …

Gene therapy for heart failure: new perspectives

K Gabisonia, FA Recchia - Current heart failure reports, 2018 - Springer
Abstract Purpose of Review The current knowledge of pathophysiological and molecular
mechanisms responsible for the genesis and development of heart failure (HF) is absolutely …

Cytoplasmic HDAC4 regulates the membrane repair mechanism in Duchenne muscular dystrophy

A Renzini, N Marroncelli, G Cavioli… - Journal of Cachexia …, 2022 - Wiley Online Library
Abstract Background Histone deacetylase 4 (HDAC4) is a stress‐responsive factor that
mediates multiple cellular responses. As a member of class IIa HDACs, HDAC4 shuttles …

Ischemia reperfusion injury provokes adverse left ventricular remodeling in dysferlin-deficient hearts through a pathway that involves TIRAP dependent signaling

S Evans, CJ Weinheimer, A Kovacs, JW Williams… - Scientific reports, 2020 - nature.com
Cardiac myocytes have multiple cell autonomous mechanisms that facilitate stabilization
and repair of damaged sarcolemmal membranes following myocardial injury. Dysferlin is a …