Evaluating intrinsic and non-intrinsic cancer risk factors
Discriminating the contribution of unmodifiable random intrinsic DNA replication errors ('bad
luck') to cancer development from those of other factors is critical for understanding cancer in …
luck') to cancer development from those of other factors is critical for understanding cancer in …
Cancer progress and priorities: breast cancer
SC Houghton, SE Hankinson - Cancer epidemiology, biomarkers & …, 2021 - AACR
Breast cancer is the most commonly diagnosed invasive cancer among women both
globally and within the United States and the number one cause of cancer-related deaths …
globally and within the United States and the number one cause of cancer-related deaths …
BOADICEA: a comprehensive breast cancer risk prediction model incorporating genetic and nongenetic risk factors
A Lee, N Mavaddat, AN Wilcox, AP Cunningham… - Genetics in …, 2019 - nature.com
Purpose Breast cancer (BC) risk prediction allows systematic identification of individuals at
highest and lowest risk. We extend the Breast and Ovarian Analysis of Disease Incidence …
highest and lowest risk. We extend the Breast and Ovarian Analysis of Disease Incidence …
Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses
Breast cancer susceptibility variants frequently show heterogeneity in associations by tumor
subtype,–. To identify novel loci, we performed a genome-wide association study including …
subtype,–. To identify novel loci, we performed a genome-wide association study including …
Collider scope: when selection bias can substantially influence observed associations
Large-scale cross-sectional and cohort studies have transformed our understanding of the
genetic and environmental determinants of health outcomes. However, the …
genetic and environmental determinants of health outcomes. However, the …
Identification of nine new susceptibility loci for endometrial cancer
Endometrial cancer is the most commonly diagnosed cancer of the female reproductive tract
in developed countries. Through genome-wide association studies (GWAS), we have …
in developed countries. Through genome-wide association studies (GWAS), we have …
A century of trends in adult human height
NCD Risk Factor Collaboration (NCD-RisC) - elife, 2016 - elifesciences.org
Being taller is associated with enhanced longevity, and higher education and earnings. We
reanalysed 1472 population-based studies, with measurement of height on more than 18.6 …
reanalysed 1472 population-based studies, with measurement of height on more than 18.6 …
Mendelian randomization analysis using mixture models for robust and efficient estimation of causal effects
G Qi, N Chatterjee - Nature communications, 2019 - nature.com
Mendelian randomization (MR) has emerged as a major tool for the investigation of causal
relationship among traits, utilizing results from large-scale genome-wide association studies …
relationship among traits, utilizing results from large-scale genome-wide association studies …
Polygenic epidemiology
F Dudbridge - Genetic epidemiology, 2016 - Wiley Online Library
Much of the genetic basis of complex traits is present on current genotyping products, but the
individual variants that affect the traits have largely not been identified. Several traditional …
individual variants that affect the traits have largely not been identified. Several traditional …
Systematic review of Mendelian randomization studies on risk of cancer
G Markozannes, A Kanellopoulou, O Dimopoulou… - BMC medicine, 2022 - Springer
Background We aimed to map and describe the current state of Mendelian randomization
(MR) literature on cancer risk and to identify associations supported by robust evidence …
(MR) literature on cancer risk and to identify associations supported by robust evidence …