Endogenous bioactive lipids are part of a complex network that modulates a plethora of
cellular and molecular processes involved in health and disease, of which inflammation …

Under conditions leading to aging and metabolic syndrome, the hypothalamus atypically
undergoes proinflammatory signaling activation leading to a chronic and stable background …

Vitamin K is a fat-soluble nutrient discovered in 1935 and its role in blood coagulation has
been thoroughly explored. In recent years, studies conducted in vitro and on animals …

Lipids, defined by low solubility in water and high solubility in nonpolar solvents, can be
classified into fatty acids, glycerolipids, glycerophospholipids, sphingolipids, and sterols …

The central nervous system is characterized by a high content of sphingolipids and by a high
diversity in terms of different structures. Stage-and cell-specific sphingolipid metabolism and …

Gangliosides (sialic acid-containing glycosphingolipids) are abundant in neurons of all
animal species and play important roles in many cell physiological processes, including …

Sphingomyelin (SM) supports brain myelination, a process closely associated with cognitive
maturation. The presence of SM in breast milk suggests a role in infant nutrition; however …

Sphingosine-1-phosphate (S1P), via its G-protein-coupled receptors, is a signaling molecule
with important regulatory properties on numerous, widely varied cell types. Five S1P …

The extracellular matrix (ECM) of the central nervous system (CNS) occupies a large part of
the neural tissue. It serves a variety of functions ranging from support of cell migration and …

Sphingolipids are ubiquitous building blocks of eukaryotic cell membranes that function as
signaling molecules for regulating a diverse range of cellular processes, including cell …