Curved membranes are key features of intracellular organelles, and their generation
involves dynamic protein complexes. Here we describe the fundamental mechanisms such …

Endocytosis allows cells to transport particles and molecules across the plasma membrane.
In addition, it is involved in the termination of signalling through receptor downmodulation …

During clathrin-mediated endocytosis, dozens of proteins assemble into an interconnected
network at the plasma membrane. As initiators of endocytosis, Eps15 and Fcho1/2 …

Force generation by actin assembly shapes cellular membranes. An experimentally
constrained multiscale model shows that a minimal branched actin network is sufficient to …

Clathrin-mediated endocytosis is the primary pathway for receptor and cargo internalization
in eukaryotic cells. It is characterized by a polyhedral clathrin lattice that coats budding …

Deformability of the plasma membrane, the outermost surface of metazoan cells, allows cells
to be dynamic, mobile and flexible. Factors that affect this deformability, such as tension on …

Reticular adhesions (RAs) consist of integrin αvβ5 and harbor flat clathrin lattices (FCLs),
long-lasting structures with similar molecular composition as clathrin-mediated endocytosis …

Clathrin-mediated endocytosis (CME) requires energy input from actin polymerization in
mechanically challenging conditions. The roles of actin in CME are poorly understood due to …

Actin assembly facilitates vesicle formation in several trafficking pathways, including clathrin-
mediated endocytosis (CME). Interestingly, actin does not assemble at all CME sites in …

The epidermal growth factor (EGF) receptor (EGFR) controls many aspects of cell
physiology. EGF binding to EGFR elicits the membrane recruitment and activation of …