Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease associated with
synovial tissue proliferation, pannus formation, cartilage destruction, and systemic …

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a cytokine that drives the
generation of myeloid cell subsets including neutrophils, monocytes, macrophages, and …

Deciphering the molecular downstream consequences of severe acute respiratory
syndrome coronavirus (SARS-CoV)− 2 infection is important for a greater understanding of …

cov-Abstract Emerging studies from SARS-CoV-2-infected patients indicate a preponderant
role of monocytes/macrophages in the pathogenesis of this viral infection, in a similar way to …

Eosinophils are bone marrow‐derived granulocytes and are found in low numbers in the
peripheral blood of healthy subjects. In type 2 inflammatory diseases, eosinopoiesis in the …

Single-cell RNA sequencing (scRNA-seq) provides unique insights into the pathology and
cellular origin of disease. We introduce single-cell disease relevance score (scDRS), an …

All nucleated cells express major histocompatibility complex I and interferon‐γ (IFNγ)
receptor, but an epithelial cell-specific function of IFNγ signalling or antigen presentation by …

The COVID-19 pandemic is a global public health crisis, with considerable mortality and
morbidity exerting pressure on health-care resources, including critical care. An excessive …

Trained immunity refers to the innate immune system building memory‐like features in
response to subsequent infections and vaccinations. Compared with classical tumor …

The introduction of immune checkpoint inhibitors has demonstrated significant
improvements in survival for subsets of cancer patients. However, they carry significant and …