The nuclear factor-κB (NF-κB) family of transcription factors is activated by canonical and
non-canonical signalling pathways, which differ in both signalling components and …

NF-κB-inducing kinase (NIK), the essential upstream kinase, which regulates activation of
the noncanonical NF-κB pathway, has important roles in regulating immunity and …

The IκB kinase (IKK) complex is the signal integration hub for NF‐κB activation. Composed
of two serine‐threonine kinases (IKK α and IKK β) and the regulatory subunit NEMO (also …

Nuclear factor (NF)-κB transcription factors are pivotal regulators of innate and adaptive
immune responses, and perturbations of NF-κB signaling contribute to the pathogenesis of …

Moderate concentrations of reactive oxygen species (ROS) are produced by diverse sources
under physiological conditions. At such low levels, these molecules may act as upstream …

Abstract Receptor Interacting Protein Kinases (RIPKs) are a family of Ser/Thr/Tyr kinases
whose functions, regulation and pathophysiologic roles have remained an enigma for a long …

NF-κB-inducing kinase (NIK) mediates non-canonical NF-κB signaling downstream of
multiple TNF family members, including BAFF, TWEAK, CD40, and OX40, which are …

Primary immunodeficiency disorders enable identification of genes with crucial roles in the
human immune system. Here we study patients suffering from recurrent bacterial, viral and …

Lymphotoxin β-receptor (LTβR) signalling promotes lymphoid neogenesis and the
development of tertiary lymphoid structures,, which are associated with severe chronic …

The cellular kinases inhibitory-κB kinase (IKK) α and Nuclear Factor-κB (NF-κB)-inducing
kinase (NIK) are well recognised as key central regulators and drivers of the non-canonical …