Summary Introduction Matrix metalloproteinases (MMPs) and 'aggrecanase'a disintegrin
and metalloproteinase with thrombospondin motifs (ADAMTSs) are well established to play …

For decades, disintegrin and metalloproteinase 17 (ADAM17) has been the object of deep
investigation. Since its discovery as the tumor necrosis factor convertase, it has been …

Articular chondrocytes are quiescent, fully differentiated cells responsible for the
homeostasis of adult articular cartilage by maintaining cellular survival functions and the fine …

Highlights•Different OA etiologies present a challenge for developing a single targeted
therapy.•Common mechanisms occur in inflammatory, mechanical, and oxidative stress in …

The metalloproteinase ADAM17 (a disintegrin and metalloprotease 17) controls EGF
receptor (EGFR) signaling by liberating EGFR ligands from their membrane anchor …

Most of our bones form through the process of endochondral ossification, which is tightly
regulated by the activity of the cartilage growth plate. Chondrocyte maturation through the …

Interleukin 6 (IL-6) supports development of bone-resorbing osteoclasts by acting early in
the osteoblast lineage via membrane-bound (cis) or soluble (trans) receptors. Here, we …

Several membrane-bound proteins with a single transmembrane domain are subjected to
limited proteolysis at the cell surface. This cleavage leads to the release of their biologically …

Mice deficient in epidermal growth factor receptor (Egfr−/− mice) are growth retarded and
exhibit severe bone defects that are poorly understood. Here we show that EGFR-deficient …

Wnt signalling pathways have key roles in joint development, homeostasis and disease,
particularly in osteoarthritis. New data is starting to reveal the importance of tightly regulating …