Data-driven modelling of neurodegenerative disease progression: thinking outside the black box

AL Young, NP Oxtoby, S Garbarino, NC Fox… - Nature Reviews …, 2024 - nature.com
Data-driven disease progression models are an emerging set of computational tools that
reconstruct disease timelines for long-term chronic diseases, providing unique insights into …

The future of disentangling the heterogeneity of autism with neuroimaging studies

X Duan, X Shan, LQ Uddin, H Chen - Biological Psychiatry, 2024 - Elsevier
Autism spectrum disorder (ASD) is a lifelong neurodevelopmental condition. Over the past
decade, a considerable number of approaches have been developed to identify potential …

Brain structural and functional abnormalities in affective network are associated with anxious depression

Q Juan, T Shiwan, S Yurong, S Jiabo, C Yu, T Shui… - BMC psychiatry, 2024 - Springer
Background Anxious depression (AD) is a common subtype of major depressive disorder
(MDD). Neuroimaging studies of AD have revealed inconsistent and heterogeneous brain …

Genetic influences on the intrinsic and extrinsic functional organizations of the cerebral cortex

B Zhao, T Li, SM Smith, Z Fan, X Yang, Y Yang, J Shu… - medRxiv, 2021 - medrxiv.org
The human cerebral cortex is a vital component of brain function, but the genetic influences
on cortical functional organization remain poorly understood. In this study, we used a …

Brain Age Is Not a Significant Predictor of Relapse Risk in Late-Life Depression

HT Karim, A Gerlach, MA Butters, R Krafty… - Biological Psychiatry …, 2024 - Elsevier
Background Late-life depression (LLD) has been associated cross-sectionally with lower
brain structural volumes and accelerated brain aging compared with healthy control …

Influence of depression severity on interhemispheric functional integration: an analysis from the REST-meta-MDD database

J Ding, J Peng, Q Zhang - Brain Imaging and Behavior, 2024 - Springer
Major depressive disorder (MDD) is a pervasive mental disorder that significantly impairs
functional capabilities, underscoring the necessity for precise stratification of its severity to …

Brain heterogeneity in 1,792 individuals with schizophrenia: effects of illness stage, sites of origin and pathophysiology

Y Jiang, L Palaniyappan, X Chang, J Zhang, E Zhou… - medRxiv, 2024 - medrxiv.org
Importance: Schizophrenia is characterized with greater variability beyond the mean
differences in brain structures. This variability is often assumed to be static, reflecting the …

Identification of distinct trajectories in preclinical type 2 diabetes and their associations with outcomes

Z Huang - medRxiv, 2024 - medrxiv.org
Type 2 Diabetes Mellitus (T2DM) is increasingly prevalent and significantly impacts patients'
lives. However, the phenotypic and genetic heterogeneity of the preclinical stage of T2DM …

Multi-Scale Characterization of Distance-dependent Functional Dysconnections in Major Depressive Disorder Across Two Asian Cohorts: A Genomic, Neurochemical …

R Qian, H Gao, B Qiu, Z Li, B Gu, T Ye, D Wu… - medRxiv, 2024 - medrxiv.org
Major Depressive Disorder (MDD) is a prevalent, chronic, and multidimensional mental
disorder characterized by widespread functional dysconnectivity in the whole brain …

[PDF][PDF] RAPIDLY TRADING DOWN DEPRESSION'S 3 PILLARS TO 5HT3-RECEPTORS THROUGH ECT OR PSILOCYBIN?

GRS Treviranus - Psychiatria Danubina, 2024 - researchgate.net
Depression astonishingly can be stopped instantly by electrotherapies or through some
psychedelics like psilocybin. In explaining this, the traditional approaches to their …