This article gives an overview of recent progress in protein-protein docking and it identifies
several directions for future research. Recent results from the CAPRI blind docking …

The prediction of the quaternary structure of biomolecular macromolecules is of paramount
importance for fundamental understanding of cellular processes and drug design. In the era …

Protein interactions define the homeostatic state of the cell. Our ability to understand these
interactions and their role in both health and disease is tied to our knowledge of the 3D …

Computational docking is the prediction or modeling of the three-dimensional structure of a
biomolecular complex, starting from the structures of the individual molecules in their free …

Here we present version 2.0 of HADDOCK, which incorporates considerable improvements
and new features. HADDOCK is now able to model not only protein–protein complexes but …

Although functional diversity in polyubiquitin chain signaling has been ascribed to the ability
of differently linked chains to bind in a distinctive manner to effector proteins, structural …

Ubiquitin modification of proteins is used as a signal in many cellular processes. Lysine side-
chains can be modified by a single ubiquitin or by a polyubiquitin chain, which is defined by …

Post-translational substrate modification with ubiquitin is essential for eukaryotic cellular
signaling. Polymeric ubiquitin chains are assembled with specific architectures, which …

Ubiquilin/PLIC proteins belong to the family of UBL–UBA proteins implicated in the
regulation of the ubiquitin-dependent proteasomal degradation of cellular proteins. A human …

Ubiquitination is one of the most utilized posttranslational modifications in eukaryotes and is
involved in a wide range of cellular processes, but is mostly known as a signal for …