Abstract Model-informed precision dosing (MIPD) stands as a significant development in
personalized medicine to tailor drug dosing to individual patient characteristics. MIPD moves …

Background: Tacrolimus (Tac, or FK506), a calcineurin inhibitor (CNI), is the first-line
immunosuppressant which consists of the footstone as immunosuppressive regimens in …

The calcineurin inhibitor tacrolimus is the backbone of immunosuppressive drug therapy
after solid organ transplantation. Tacrolimus is effective in preventing acute rejection but has …

The aim of this work is to estimate the area‐under the blood concentration curve of
tacrolimus (TAC) following bid or qd dosing in organ transplant patients, using Xgboost …

Posttransplant immunosuppressive drugs such as tacrolimus have narrow therapeutic
ranges. Inter-and intraindividual variability in dosing requirements conventionally use …

ABSTRACT Introduction: Tacrolimus (Tac) is effective in preventing acute rejection but has
considerable toxicity and inter-individual variability in pharmacokinetics and …

Purpose To identify patient characteristics that influence tacrolimus individual dose
requirement in kidney transplant recipients. Methods Data on forty-four 12-h …

We previously demonstrated that Machine learning (ML) algorithms can accurately estimate
drug area under the curve (AUC) of tacrolimus or mycophenolate mofetil (MMF) based on …

Population pharmacokinetic modelling is widely used within the field of clinical
pharmacology as it helps to define the sources and correlates of pharmacokinetic variability …

Abstract Background and Objectives Numerous population pharmacokinetic (PK) models of
tacrolimus in adult transplant recipients have been published to characterize tacrolimus PK …