Astrocytes are abundant glial cells in the central nervous system (CNS) that perform diverse
functions in health and disease. Astrocyte dysfunction is found in numerous diseases …

Microglial cells are the resident macrophages in the central nervous system. These cells of
mesodermal/mesenchymal origin migrate into all regions of the central nervous system …

Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by central nervous
(CNS) demyelination resulting in axonal injury and neurological deficits. Essentially, MS is …

PARP-1 (poly (ADP-ribose)-polymerase 1), mainly known for its protective role in DNA
repair, also regulates inflammatory processes. Notably, defects in DNA repair and chronic …

PARPs and tankyrases (TNKS) represent a family of 17 proteins. PARPs and tankyrases
were originally identified as DNA repair factors, nevertheless, recent advances have shed …

Neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease
(PD), are characterized by progressive memory loss and motor impairment. Aging is a major …

Astrocytes have complex roles in health and disease, thus it is important to study the
pathways that regulate their function. Here we report that lactosylceramide (LacCer) …

The abundant nuclear enzyme PARP-1, a multifunctional regulator of chromatin structure,
transcription, and genomic integrity, plays key roles in a wide variety of processes in the …

Seasonal changes in disease activity have been observed in multiple sclerosis, an
autoimmune disorder that affects the CNS. These epidemiological observations suggest that …

The immunological process of clonal selection requires a rapid burst in lymphocyte
proliferation, and this involves a metabolic shift to provide energy and the building blocks of …