Function and therapeutic value of astrocytes in neurological diseases
Astrocytes are abundant glial cells in the central nervous system (CNS) that perform diverse
functions in health and disease. Astrocyte dysfunction is found in numerous diseases …
functions in health and disease. Astrocyte dysfunction is found in numerous diseases …
Physiology of microglia
H Kettenmann, UK Hanisch, M Noda… - Physiological …, 2011 - journals.physiology.org
Microglial cells are the resident macrophages in the central nervous system. These cells of
mesodermal/mesenchymal origin migrate into all regions of the central nervous system …
mesodermal/mesenchymal origin migrate into all regions of the central nervous system …
[HTML][HTML] Ferroptosis contributes to multiple sclerosis and its pharmacological targeting suppresses experimental disease progression
E Van San, AC Debruyne, G Veeckmans… - Cell Death & …, 2023 - nature.com
Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by central nervous
(CNS) demyelination resulting in axonal injury and neurological deficits. Essentially, MS is …
(CNS) demyelination resulting in axonal injury and neurological deficits. Essentially, MS is …
[HTML][HTML] Multifaceted role of PARP-1 in DNA repair and inflammation: pathological and therapeutic implications in cancer and non-cancer diseases
S Pazzaglia, C Pioli - Cells, 2019 - mdpi.com
PARP-1 (poly (ADP-ribose)-polymerase 1), mainly known for its protective role in DNA
repair, also regulates inflammatory processes. Notably, defects in DNA repair and chronic …
repair, also regulates inflammatory processes. Notably, defects in DNA repair and chronic …
[HTML][HTML] PARPs in lipid metabolism and related diseases
PARPs and tankyrases (TNKS) represent a family of 17 proteins. PARPs and tankyrases
were originally identified as DNA repair factors, nevertheless, recent advances have shed …
were originally identified as DNA repair factors, nevertheless, recent advances have shed …
The role of PARP1 in neurodegenerative diseases and aging
K Mao, G Zhang - The FEBS journal, 2022 - Wiley Online Library
Neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease
(PD), are characterized by progressive memory loss and motor impairment. Aging is a major …
(PD), are characterized by progressive memory loss and motor impairment. Aging is a major …
Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation
L Mayo, SA Trauger, M Blain, M Nadeau, B Patel… - Nature medicine, 2014 - nature.com
Astrocytes have complex roles in health and disease, thus it is important to study the
pathways that regulate their function. Here we report that lactosylceramide (LacCer) …
pathways that regulate their function. Here we report that lactosylceramide (LacCer) …
[HTML][HTML] The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets
R Krishnakumar, WL Kraus - Molecular cell, 2010 - cell.com
The abundant nuclear enzyme PARP-1, a multifunctional regulator of chromatin structure,
transcription, and genomic integrity, plays key roles in a wide variety of processes in the …
transcription, and genomic integrity, plays key roles in a wide variety of processes in the …
[HTML][HTML] Melatonin contributes to the seasonality of multiple sclerosis relapses
Seasonal changes in disease activity have been observed in multiple sclerosis, an
autoimmune disorder that affects the CNS. These epidemiological observations suggest that …
autoimmune disorder that affects the CNS. These epidemiological observations suggest that …
Metabolic checkpoints in activated T cells
R Wang, DR Green - Nature immunology, 2012 - nature.com
The immunological process of clonal selection requires a rapid burst in lymphocyte
proliferation, and this involves a metabolic shift to provide energy and the building blocks of …
proliferation, and this involves a metabolic shift to provide energy and the building blocks of …