Chemistry for Positron Emission Tomography: Recent Advances in 11C‐, 18F‐, 13N‐, and 15O‐Labeling Reactions

X Deng, J Rong, L Wang, N Vasdev… - Angewandte Chemie …, 2019 - Wiley Online Library
Positron emission tomography (PET) is a molecular imaging technology that provides
quantitative information about function and metabolism in biological processes in vivo for …

Copper-mediated late-stage radiofluorination: five years of impact on preclinical and clinical PET imaging

JS Wright, T Kaur, S Preshlock, SS Tanzey… - Clinical and translational …, 2020 - Springer
Purpose Copper-mediated radiofluorination (CMRF) is emerging as the method of choice for
the formation of aromatic C–18 F bonds. This minireview examines proof-of-concept …

New methodologies for the preparation of carbon-11 labeled radiopharmaceuticals

K Dahl, C Halldin, M Schou - Clinical and Translational Imaging, 2017 - Springer
Purpose This short review aims to cover the more recent and promising developments of
carbon-11 (11 C) labeling radiochemistry and its utility in the production of novel …

11 C [double bond, length as m-dash] O bonds made easily for positron emission tomography radiopharmaceuticals

BH Rotstein, SH Liang, MS Placzek… - Chemical Society …, 2016 - pubs.rsc.org
The positron-emitting radionuclide carbon-11 (11C, t1/2= 20.3 min) possesses the unique
potential for radiolabeling of any biological, naturally occurring, or synthetic organic …

Recent progress in [11C]carbon dioxide ([11C]CO2) and [11C]carbon monoxide ([11C]CO) chemistry

C Taddei, AD Gee - Journal of Labelled Compounds and …, 2018 - Wiley Online Library
[11C] Carbon dioxide ([11C] CO2) and [11C] carbon monoxide ([11C] CO) are 2 attractive
precursors for labelling the carbonyl position (C═ O) in a vast range of functionalised …

Carboxylation of Aryl Triflates with CO2 Merging Palladium and Visible-Light-Photoredox Catalysts

SK Bhunia, P Das, S Nandi, R Jana - Organic letters, 2019 - ACS Publications
We report herein a visible-light-promoted, highly practical carboxylation of readily accessible
aryl triflates at ambient temperature and a balloon pressure of CO2 by the combined use of …

Recent developments in carbon-11 chemistry and applications for first-in-human PET studies

A Pees, M Chassé, A Lindberg, N Vasdev - Molecules, 2023 - mdpi.com
Positron emission tomography (PET) is a molecular imaging technique that makes use of
radiolabelled molecules for in vivo evaluation. Carbon-11 is a frequently used radionuclide …

[HTML][HTML] A randomized controlled study to evaluate the effect of bexarotene on amyloid-β and apolipoprotein E metabolism in healthy subjects

K Ghosal, M Haag, PB Verghese, T West… - Alzheimer's & Dementia …, 2016 - Elsevier
Introduction We conducted a phase Ib proof of mechanism trial to determine whether
bexarotene (Targretin) increases central nervous system (CNS) apolipoprotein E (apoE) …

Activation of RXR/PPARγ underlies neuroprotection by bexarotene in ischemic stroke

M Certo, Y Endo, K Ohta, S Sakurada, G Bagetta… - Pharmacological …, 2015 - Elsevier
The identification of novel drug targets for the treatment of ischemic stroke is currently an
urgent challenge. Recent experimental findings have highlighted the neuroprotective …

Boron reagents for divergent radiochemistry

TC Wilson, T Cailly, V Gouverneur - Chemical Society Reviews, 2018 - pubs.rsc.org
Radiolabelled (bio) molecules have advanced many areas of science from fundamental
biology to human health including applications in molecular imaging and more generally …