[HTML][HTML] Overcoming cancer therapeutic bottleneck by drug repurposing

Z Zhang, L Zhou, N Xie, EC Nice, T Zhang… - Signal transduction and …, 2020 - nature.com
Ever present hurdles for the discovery of new drugs for cancer therapy have necessitated
the development of the alternative strategy of drug repurposing, the development of old …

[HTML][HTML] Molecular mechanisms of action of genistein in cancer: Recent advances

HS Tuli, MJ Tuorkey, F Thakral, K Sak… - Frontiers in …, 2019 - frontiersin.org
Background: Genistein is one among the several other known isoflavones that is found in
different soybeans and soy products. The chemical name of genistein is 4′, 5, 7 …

[HTML][HTML] Thymoquinone (2-Isopropyl-5-methyl-1, 4-benzoquinone) as a chemopreventive/anticancer agent: Chemistry and biological effects

A Ahmad, RK Mishra, A Vyawahare, A Kumar… - Saudi Pharmaceutical …, 2019 - Elsevier
Cancer remains the topmost disorder of the mankind and number of cases is unceasingly
growing at unprecedented rates. Although the synthetic anti-cancer compounds still hold the …

Natural products for cancer therapy: a review of their mechanism of actions and toxicity in the past decade

YO Ali Abdalla, B Subramaniam… - Journal of Tropical …, 2022 - Wiley Online Library
The ethnopharmacological information gathered over many centuries and the presence of
diverse metabolites have made the medicinal plants as the prime source of drugs. Despite …

Targeting PI3K/Akt signaling in prostate cancer therapy

M Hashemi, A Taheriazam, P Daneii… - Journal of Cell …, 2023 - Springer
Urological cancers have obtained much attention in recent years due to their mortality and
morbidity. The most common and malignant tumor of urological cancers is prostate cancer …

Therapeutic potentials of genistein: New insights and perspectives

S Rasheed, K Rehman, M Shahid… - Journal of Food …, 2022 - Wiley Online Library
Genistein, a polyphenolic isoflavone compound found abundantly in soy or soy‐based
products, is widely consumed in the Asian population. Genistein has poor bioavailability, to …

[HTML][HTML] Inhibition of Cancer Development by Natural Plant Polyphenols: Molecular Mechanisms

A Lyubitelev, V Studitsky - International Journal of Molecular Sciences, 2023 - mdpi.com
Malignant tumors remain one of the main sources of morbidity and mortality around the
world. A chemotherapeutic approach to cancer treatment poses a multitude of challenges …

[HTML][HTML] Effects of flavonoids on cancer, cardiovascular and neurodegenerative diseases: Role of NF-κB signaling pathway

MM Barreca, R Alessandro, C Corrado - International Journal of …, 2023 - mdpi.com
Flavonoids are polyphenolic phytochemical compounds found in many plants, fruits,
vegetables, and leaves. They have a multitude of medicinal applications due to their anti …

[HTML][HTML] Anticancer effects of natural phytochemicals in anaplastic thyroid cancer

Y Li, J Zhang, H Zhou, Z Du - Oncology Reports, 2022 - spandidos-publications.com
Anaplastic thyroid cancer (ATC) is an aggressive and lethal malignancy having a dismal
prognosis. Phytochemicals are bioactive components obtained from plants that have been …

Thymoquinone inhibits proliferation and migration of MDA-MB-231 triple negative breast cancer cells by suppressing autophagy, Beclin-1 and LC3

TD Ünal, Z Hamurcu, N Delibaşı, V Çınar… - Anti-Cancer Agents …, 2021 - ingentaconnect.com
Background: Triple Negative Breast Cancer (TNBC) is an aggressive and highly
heterogeneous subtype of breast cancer associated with poor prognosis. A better …