Prostate cancer (PCa) incidence and mortality have rapidly increased in China. Notably,
unique epidemiological characteristics of PCa are found in the Chinese PCa population …

The nuclear speckle-type pox virus and zinc finger (POZ) protein (SPOP), a representative
substrate-recognition subunit of the cullin-RING E3 ligase, has been characterized to play a …

The initiation and progression of cancer is dependent on the acquisition of mutations in
oncogenes or tumor suppressor genes that ultimately leads to the dysregulation of key …

Abstract Purpose of Review This review will examine the taxonomy of PCa subclasses
across disease states, explore the relationship among specific alterations, and highlight …

Multiple studies have confirmed that speckle-type pox virus and zinc finger (POZ) protein
(SPOP) functions as a substrate adaptor of cullin 3-based E3 ligase and has a crucial role in …

Prostate cancer is a clinically heterogeneous disease, with some men having indolent
disease that can safely be observed, while others have aggressive, lethal disease. Over the …

The E3 ubiquitin ligase adaptor speckle-type POZ protein (SPOP) is frequently dysregulated
in prostate adenocarcinoma (PC), via either somatic mutations or mRNA downregulation …

Black men with prostate cancer have historically had worse outcomes than white men with
prostate cancer. The causes of this disparity in outcomes are multi-factorial, but a potential …

Ubiquitin-mediated protein degradation is the primary biological process by which protein
abundance is regulated and protein homeostasis is maintained in eukaryotic cells. Speckle …

SPOP, an E3 ubiquitin ligase, acts as a prostate-specific tumor suppressor with several key
substrates mediating oncogenic function. However, the mechanisms underlying SPOP …