Niacin (also known as “vitamin B3” or “vitamin PP”) includes two vitamers (nicotinic acid and
nicotinamide) giving rise to the coenzymatic forms nicotinamide adenine dinucleotide (NAD) …

The coupling of nicotinamide adenine dinucleotide (NAD+) breakdown and protein
deacylation is a unique feature of the family of proteins called 'sirtuins.'This intimate …

Mitochondria are intracellular powerhouses that produce ATP and carry out diverse
functions for cellular energy metabolism. Although the maintenance of an optimal …

Summary SARM1 is an NAD (P) glycohydrolase and TLR adapter with an essential,
prodegenerative role in programmed axon death (Wallerian degeneration). Like other NAD …

Objective A decay in intracellular NAD+ levels is one of the hallmarks of physiological
decline in normal tissue functions. Accordingly, dietary supplementation with NAD+ …

NAD is a vital redox carrier, and its degradation is a key element of important regulatory
pathways. NAD-mediated functions are compartmentalized and have to be fueled by specific …

The metabolism of NAD has emerged as a key regulator of cellular and organismal
homeostasis. Being a major component of both bioenergetic and signaling pathways, the …

Nicotinamide adenine dinucleotide (NAD+) is a coenzyme for hydride transfer reactions and
a substrate for sirtuins and other NAD+-consuming enzymes. The abundance of NAD+ …

Macrophages play an essential role in alcohol-induced inflammation and oxidative stress.
We investigated the effects of nicotinamide riboside (NR), a natural nicotinamide adenine …

NAD is essential for cellular metabolism and has a key role in various signaling pathways in
human cells. To ensure proper control of vital reactions, NAD must be permanently …