[HTML][HTML] Molecular biology of hepatitis B virus infection

C Seeger, WS Mason - Virology, 2015 - Elsevier
Human hepatitis B virus (HBV) is the prototype of a family of small DNA viruses that
productively infect hepatocytes, the major cell of the liver, and replicate by reverse …

Complete and incomplete hepatitis B virus particles: formation, function, and application

J Hu, K Liu - Viruses, 2017 - mdpi.com
Hepatitis B virus (HBV) is a para-retrovirus or retroid virus that contains a double-stranded
DNA genome and replicates this DNA via reverse transcription of a RNA pregenome. Viral …

Core protein: A pleiotropic keystone in the HBV lifecycle

A Zlotnick, B Venkatakrishnan, Z Tan, E Lewellyn… - Antiviral research, 2015 - Elsevier
Abstract Hepatitis B Virus (HBV) is a small virus whose genome has only four open reading
frames. We argue that the simplicity of the virion correlates with a complexity of functions for …

[HTML][HTML] Hepatitis B virus molecular biology and pathogenesis

RJ Lamontagne, S Bagga, MJ Bouchard - Hepatoma research, 2016 - ncbi.nlm.nih.gov
As obligate intracellular parasites, viruses need a host cell to provide a milieu favorable to
viral replication. Consequently, viruses often adopt mechanisms to subvert host cellular …

Revisiting hepatitis B virus: challenges of curative therapies

J Hu, U Protzer, A Siddiqui - Journal of virology, 2019 - Am Soc Microbiol
With a yearly death toll of 880,000, hepatitis B virus (HBV) remains a major health problem
worldwide, despite an effective prophylactic vaccine and well-tolerated, effective antivirals …

[HTML][HTML] Hepatitis B virus replication

J Beck, M Nassal - World journal of gastroenterology: WJG, 2007 - ncbi.nlm.nih.gov
Hepadnaviruses, including human hepatitis B virus (HBV), replicate through reverse
transcription of an RNA intermediate, the pregenomic RNA (pgRNA). Despite this kinship to …

Targeting the multifunctional HBV core protein as a potential cure for chronic hepatitis B

U Viswanathan, N Mani, Z Hu, H Ban, Y Du, J Hu… - Antiviral research, 2020 - Elsevier
The core (capsid) protein of hepatitis B virus (HBV) is the building block of nucleocapsids
where viral DNA reverse transcriptional replication takes place and mediates virus-host cell …

Structural insights into the coupling of virion assembly and rotavirus replication

SD Trask, SM McDonald, JT Patton - Nature reviews microbiology, 2012 - nature.com
Viral replication is rapid and robust, but it is far from a chaotic process. Instead, successful
production of infectious progeny requires that events occur in the correct place and at the …

[HTML][HTML] Hepatitis B virus morphogenesis

V Bruss - World journal of gastroenterology: WJG, 2007 - ncbi.nlm.nih.gov
The hepatitis B virus (HBV) particle consists of an envelope containing three related surface
proteins and probably lipid and an icosahedral nucleocapsid of approximately 30 nm …

Intracellular trafficking of HBV particles

B Jiang, E Hildt - Cells, 2020 - mdpi.com
The human hepatitis B virus (HBV), that is causative for more than 240 million cases of
chronic liver inflammation (hepatitis), is an enveloped virus with a partially double-stranded …