Macrophages in the cochlea; an immunological link between risk factors and progressive hearing loss
K Hough, CA Verschuur, C Cunningham, TA Newman - Glia, 2022 - Wiley Online Library
Macrophages are abundant in the cochlea; however, their role in hearing loss is not well
understood. Insults to the cochlea, such as noise or insertion of a cochlear implant, cause an …
understood. Insults to the cochlea, such as noise or insertion of a cochlear implant, cause an …
Intracochlear fibrosis and the foreign body response to cochlear implant biomaterials
MJ Foggia, RV Quevedo… - Laryngoscope …, 2019 - Wiley Online Library
Objective To report current knowledge on the topic of intracochlear fibrosis and the foreign
body response following cochlear implantation (CI). Methods A literature search was …
body response following cochlear implantation (CI). Methods A literature search was …
Impedance changes and fibrous tissue growth after cochlear implantation are correlated and can be reduced using a dexamethasone eluting electrode
M Wilk, R Hessler, K Mugridge, C Jolly, M Fehr… - PloS one, 2016 - journals.plos.org
Background The efficiency of cochlear implants (CIs) is affected by postoperative connective
tissue growth around the electrode array. This tissue formation is thought to be the cause …
tissue growth around the electrode array. This tissue formation is thought to be the cause …
New molecular therapies for the treatment of hearing loss
An estimated 466 million people suffer from hearing loss worldwide. Sensorineural hearing
loss is characterized by degeneration of key structures of the sensory pathway in the …
loss is characterized by degeneration of key structures of the sensory pathway in the …
Electrode array-eluted dexamethasone protects against electrode insertion trauma induced hearing and hair cell losses, damage to neural elements, increases in …
We evaluated the effects of dexamethasone base (DXMb) containing electrode arrays in a
guinea pig model of cochlear implantation to determine if eluted DXMb could protect the …
guinea pig model of cochlear implantation to determine if eluted DXMb could protect the …
[HTML][HTML] Gene therapy for human sensorineural hearing loss
Hearing loss is the most common sensory impairment in humans and currently disables 466
million people across the world. Congenital deafness affects at least 1 in 500 newborns, and …
million people across the world. Congenital deafness affects at least 1 in 500 newborns, and …
Intracochlear drug delivery in combination with cochlear implants: Current aspects
SK Plontke, G Götze, T Rahne, A Liebau - Hno, 2016 - Springer
Die lokale Medikamentenapplikation an das Innenohr bietet eine Reihe von Vorteilen
gegenüber der systemischen Medikamentengabe. Die lokale Applikation erfolgt …
gegenüber der systemischen Medikamentengabe. Die lokale Applikation erfolgt …
Cochlear implants: causes, effects and mitigation strategies for the foreign body response and inflammation
Cochlear implants provide effective auditory rehabilitation for patients with severe to
profound sensorineural hearing loss. Recent advances in cochlear implant technology and …
profound sensorineural hearing loss. Recent advances in cochlear implant technology and …
Foreign body response to silicone in cochlear implant electrodes in the human
JT O'Malley, BJ Burgess, D Galler… - Otology & …, 2017 - journals.lww.com
Background: Clinical evidence of a foreign body response to a cochlear implant has been
reported. In a previous study, particulate material found within the fibrous sheath and within …
reported. In a previous study, particulate material found within the fibrous sheath and within …
Comparison of electrode impedance measures between a dexamethasone-eluting and standard Cochlear™ Contour Advance® electrode in adult cochlear implant …
Objective To compare the difference in electrode impedance across discrete time points to
24 months post-activation for two groups of adult cochlear implant recipients, one using an …
24 months post-activation for two groups of adult cochlear implant recipients, one using an …