Macrophages in the cochlea; an immunological link between risk factors and progressive hearing loss

K Hough, CA Verschuur, C Cunningham, TA Newman - Glia, 2022 - Wiley Online Library
Macrophages are abundant in the cochlea; however, their role in hearing loss is not well
understood. Insults to the cochlea, such as noise or insertion of a cochlear implant, cause an …

Intracochlear fibrosis and the foreign body response to cochlear implant biomaterials

MJ Foggia, RV Quevedo… - Laryngoscope …, 2019 - Wiley Online Library
Objective To report current knowledge on the topic of intracochlear fibrosis and the foreign
body response following cochlear implantation (CI). Methods A literature search was …

Impedance changes and fibrous tissue growth after cochlear implantation are correlated and can be reduced using a dexamethasone eluting electrode

M Wilk, R Hessler, K Mugridge, C Jolly, M Fehr… - PloS one, 2016 - journals.plos.org
Background The efficiency of cochlear implants (CIs) is affected by postoperative connective
tissue growth around the electrode array. This tissue formation is thought to be the cause …

New molecular therapies for the treatment of hearing loss

Y Ma, AK Wise, RK Shepherd… - Pharmacology & …, 2019 - Elsevier
An estimated 466 million people suffer from hearing loss worldwide. Sensorineural hearing
loss is characterized by degeneration of key structures of the sensory pathway in the …

Electrode array-eluted dexamethasone protects against electrode insertion trauma induced hearing and hair cell losses, damage to neural elements, increases in …

E Bas, J Bohorquez, S Goncalves, E Perez, CT Dinh… - Hearing research, 2016 - Elsevier
We evaluated the effects of dexamethasone base (DXMb) containing electrode arrays in a
guinea pig model of cochlear implantation to determine if eluted DXMb could protect the …

[HTML][HTML] Gene therapy for human sensorineural hearing loss

Y Ren, LD Landegger, KM Stankovic - Frontiers in Cellular …, 2019 - frontiersin.org
Hearing loss is the most common sensory impairment in humans and currently disables 466
million people across the world. Congenital deafness affects at least 1 in 500 newborns, and …

Intracochlear drug delivery in combination with cochlear implants: Current aspects

SK Plontke, G Götze, T Rahne, A Liebau - Hno, 2016 - Springer
Die lokale Medikamentenapplikation an das Innenohr bietet eine Reihe von Vorteilen
gegenüber der systemischen Medikamentengabe. Die lokale Applikation erfolgt …

Cochlear implants: causes, effects and mitigation strategies for the foreign body response and inflammation

MT Rahman, DA Chari, G Ishiyama, I Lopez… - Hearing research, 2022 - Elsevier
Cochlear implants provide effective auditory rehabilitation for patients with severe to
profound sensorineural hearing loss. Recent advances in cochlear implant technology and …

Foreign body response to silicone in cochlear implant electrodes in the human

JT O'Malley, BJ Burgess, D Galler… - Otology & …, 2017 - journals.lww.com
Background: Clinical evidence of a foreign body response to a cochlear implant has been
reported. In a previous study, particulate material found within the fibrous sheath and within …

Comparison of electrode impedance measures between a dexamethasone-eluting and standard Cochlear™ Contour Advance® electrode in adult cochlear implant …

R Briggs, S O'Leary, C Birman, K Plant, R English… - Hearing Research, 2020 - Elsevier
Objective To compare the difference in electrode impedance across discrete time points to
24 months post-activation for two groups of adult cochlear implant recipients, one using an …