The impact of sensory neuropathy and inflammation on epithelial wound healing in diabetic corneas

XY Fu-Shin, PSY Lee, L Yang, N Gao, Y Zhang… - Progress in retinal and …, 2022 - Elsevier
Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes, with
several underlying pathophysiological mechanisms, some of which are still uncertain. The …

Corneal nerves in health and disease

BS Shaheen, M Bakir, S Jain - Survey of ophthalmology, 2014 - Elsevier
Corneal nerves are responsible for the sensations of touch, pain, and temperature and play
an important role in the blink reflex, wound healing, and tear production and secretion …

[HTML][HTML] A single cell atlas of human cornea that defines its development, limbal progenitor cells and their interactions with the immune cells

J Collin, R Queen, D Zerti, S Bojic, B Dorgau, N Moyse… - The ocular …, 2021 - Elsevier
Purpose Single cell (sc) analyses of key embryonic, fetal and adult stages were performed to
generate a comprehensive single cell atlas of all the corneal and adjacent conjunctival cell …

Global consensus on the management of limbal stem cell deficiency

SX Deng, F Kruse, JAP Gomes, CC Chan, S Daya… - Cornea, 2020 - journals.lww.com
Purpose: In recent decades, the medical and surgical treatment of limbal stem cell deficiency
(LSCD) has evolved significantly through the incorporation of innovative pharmacological …

Neuroimmune crosstalk in the cornea: The role of immune cells in corneal nerve maintenance during homeostasis and inflammation

M Wu, LJ Hill, LE Downie, HR Chinnery - Progress in Retinal and Eye …, 2022 - Elsevier
In the cornea, resident immune cells are in close proximity to sensory nerves, consistent with
their important roles in the maintenance of nerves in both homeostasis and inflammation …

Nerve dependence in tissue, organ, and appendage regeneration

A Kumar, JP Brockes - Trends in neurosciences, 2012 - cell.com
Many regeneration contexts require the presence of regenerating nerves as a transient
component of the progenitor cell niche. Here we review nerve involvement in regeneration …

Understanding the pathogenesis of neurotrophic keratitis: the role of corneal nerves

L Mastropasqua, G Massaro‐Giordano… - Journal of cellular …, 2017 - Wiley Online Library
Neurotrophic keratitis (NK) is a rare degenerative disease of the cornea caused by
trigeminal nerve damage, which leads to loss of corneal sensitivity, corneal epithelium …

Pathophysiology of aniridia-associated keratopathy: Developmental aspects and unanswered questions

L Latta, FC Figueiredo, R Ashery-Padan, JM Collinson… - The ocular …, 2021 - Elsevier
Aniridia, a rare congenital disease, is often characterized by a progressive, pronounced
limbal insufficiency and ocular surface pathology termed aniridia-associated keratopathy …

Salivary glands regenerate after radiation injury through SOX2‐mediated secretory cell replacement

E Emmerson, AJ May, L Berthoin… - EMBO molecular …, 2018 - embopress.org
Salivary gland acinar cells are routinely destroyed during radiation treatment for head and
neck cancer that results in a lifetime of hyposalivation and co‐morbidities. A potential …

Restoration of corneal sensation with regional nerve transfers and nerve grafts: a new approach to a difficult problem

U Elbaz, R Bains, RM Zuker, GH Borschel… - JAMA …, 2014 - jamanetwork.com
Importance Corneal anesthesia is recalcitrant to conventional treatment and can lead to
permanent visual loss. Objective To assess the outcomes of a novel sensory reconstructive …