Machine learning techniques for personalised medicine approaches in immune-mediated chronic inflammatory diseases: applications and challenges

J Peng, EC Jury, P Dönnes, C Ciurtin - Frontiers in pharmacology, 2021 - frontiersin.org
In the past decade, the emergence of machine learning (ML) applications has led to
significant advances towards implementation of personalised medicine approaches for …

Artificial intelligence and machine learning approaches using gene expression and variant data for personalized medicine

S Vadapalli, H Abdelhalim, S Zeeshan… - Briefings in …, 2022 - academic.oup.com
Precision medicine uses genetic, environmental and lifestyle factors to more accurately
diagnose and treat disease in specific groups of patients, and it is considered one of the …

The pathogenesis of systemic lupus erythematosus: harnessing big data to understand the molecular basis of lupus

MD Catalina, KA Owen, AC Labonte, AC Grammer… - Journal of …, 2020 - Elsevier
Systemic lupus erythematosus (SLE) is a chronic, systemic autoimmune disease that causes
damage to multiple organ systems. Despite decades of research and available murine …

Discovering biomarkers associated and predicting cardiovascular disease with high accuracy using a novel nexus of machine learning techniques for precision …

W DeGroat, H Abdelhalim, K Patel, D Mendhe… - Scientific reports, 2024 - nature.com
Personalized interventions are deemed vital given the intricate characteristics,
advancement, inherent genetic composition, and diversity of cardiovascular diseases …

Re-focusing explainability in medicine

L Arbelaez Ossa, G Starke, G Lorenzini… - Digital …, 2022 - journals.sagepub.com
Using artificial intelligence to improve patient care is a cutting-edge methodology, but its
implementation in clinical routine has been limited due to significant concerns about …

An introduction to machine learning and analysis of its use in rheumatic diseases

KM Kingsmore, CE Puglisi, AC Grammer… - Nature Reviews …, 2021 - nature.com
Abstract Machine learning (ML) is a computerized analytical technique that is being
increasingly employed in biomedicine. ML often provides an advantage over explicitly …

Lupus or not? SLE Risk Probability Index (SLERPI): a simple, clinician-friendly machine learning-based model to assist the diagnosis of systemic lupus erythematosus

C Adamichou, I Genitsaridi, D Nikolopoulos… - Annals of the …, 2021 - ard.bmj.com
Objectives Diagnostic reasoning in systemic lupus erythematosus (SLE) is a complex
process reflecting the probability of disease at a given timepoint against competing …

Drug repurposing to improve treatment of rheumatic autoimmune inflammatory diseases

KM Kingsmore, AC Grammer, PE Lipsky - Nature Reviews …, 2020 - nature.com
The past century has been characterized by intensive efforts, within both academia and the
pharmaceutical industry, to introduce new treatments to individuals with rheumatic …

Leveraging heterogeneity in systemic lupus erythematosus for new therapies

ME Allen, V Rus, GL Szeto - Trends in molecular medicine, 2021 - cell.com
Systemic lupus erythematosus (SLE) is a multisystem, chronic autoimmune disease where
treatment varies by patient and disease activity. Strong preclinical results and clinical …

Deep learning classification of systemic sclerosis skin using the MobileNetV2 model

M Akay, Y Du, CL Sershen, M Wu… - IEEE Open Journal …, 2021 - ieeexplore.ieee.org
Goal: Systemic sclerosis (SSc) is a rare autoimmune, systemic disease with prominent
fibrosis of skin and internal organs. Early diagnosis of the disease is crucial for designing …