Transient receptor potential canonical (TRPC) channels constitute a group of receptor-
operated calcium-permeable nonselective cation channels of the TRP superfamily. The …

Sodium tanshinone IIA sulfonate (STS) is a water-soluble derivate of tanshinone IIA (Tan IIA)
which is an active lipophilic constitute of Chinese Materia Medica Salvia miltiorrhiza …

Medicinal plant‐derived bioactive compounds modulate multiple therapeutic targets in
cardiovascular diseases (CVDs), rendering herb‐derived phytochemicals effective against …

Pulmonary arterial hypertension (PAH) is characterized by pulmonary artery remodeling that
may subsequently culminate in right heart failure and premature death. Although there are …

Heart failure (HF) is the end stage of several cardiovascular diseases with high mortality
worldwide; however, current chemical drugs have not beneficial effect on reducing its …

Aberrant activation of hypoxia-inducible factor (HIF)-1α is frequently encountered and
promotes oxidative stress and inflammation in chronic obstructive pulmonary disease …

Increasing evidence indicates that patients or experimental animals exposure to endotoxin
(lipopolysaccharides, LPS) exert deleterious cardiac functions that greatly contribute to …

Emphysema is one of the most important phenotypes for chronic obstructive pulmonary
disease (COPD). Apoptosis in alveolar epithelial cells (AECs) causes the emphysematous …

Previous studies have demonstrated that besides the classic canonical transient receptor
potential channel family, Orai family and stromal interaction molecule 1 (STIM1) might also …

Background/Aims: The proliferation of human bronchial smooth muscle cells (HBSMCs) is a
key pathophysiological component of airway remodeling in chronic obstructive pulmonary …