Although eosinophilic inflammation is characteristic of asthma pathogenesis, neutrophilic
inflammation is also marked, and eosinophils and neutrophils can coexist in some cases …

It is now established that airway smooth muscle (ASM) has roles in determining airway
structure and function, well beyond that as the major contractile element. Indeed, changes in …

Increased airway smooth muscle (ASM) mass is a hallmark of airway remodeling in severe
asthma. Th17‐associated cytokines, particularly IL‐17A, IL‐17F, and IL‐22, have been …

Rationale Increased IL-8 levels and neutrophil accumulation in the airways are common
features found in patients affected by pulmonary diseases such as Asthma, Idiopathic …

Recently, the serum levels of YKL-40, a chitinase-like glycoprotein, have been shown to be
significantly elevated in asthmatics and are associated with asthma severity. Although these …

Background: In a subset of severe asthma patients, chronic airway inflammation is
associated with infiltration of neutrophils, Th-17 cells and elevated expression of Th-17 …

Background Eosinophils, a central factor in asthma pathogenesis, have the ability to secrete
exosomes. However, the precise role played by exosomes in the biological processes …

Asthma is characterized by the association of airway hyperresponsiveness (AHR),
inflammation, and remodelling. The aim of the present article is to review the pivotal role of …

In the pathophysiology of asthma, structural cell dysfunction and concomitant
microenvironment changes in airways are crucial to pathological progression, which …

Galangin, a natural flavonol, has attracted much attention for its potential anti-inflammatory
properties. However, its role in the regulation of airway remodelling in asthma has not been …