Aging is the greatest risk factor for a multitude of diseases including cardiovascular disease,
neurodegeneration and cancer. Despite decades of research dedicated to understanding …

Reactive oxygen species (ROS) and cellular oxidative stress are involved in many
physiological and pathophysiological processes, including cellular and organismal aging …

In Drosophila, intestinal stem cells (ISCs) respond to oxidative challenges and inflammation
by increasing proliferation rates. This phenotype is part of a regenerative response, but can …

Regenerative processes are critical to maintain tissue homeostasis in high-turnover tissues.
At the same time, proliferation of stem and progenitor cells has to be carefully controlled to …

Mitochondrial dysfunction plays important roles in many diseases, but there is no satisfactory
method to assess mitochondrial health in vivo. Here, we engineered a MitoTimer reporter …

The reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) protects
against redox stress by providing reducing equivalents to antioxidants such as glutathione …

Evolutionary theories of aging predict the existence of certain genes that provide selective
advantage early in life with adverse effect on lifespan later in life (antagonistic pleiotropy …

Caloric restriction (CR) extends the lifespan of flies, worms, and yeast by counteracting age-
related oxidation of H 2 O 2-scavenging peroxiredoxins (Prxs). Here, we show that …

Summary Eukaryotic 2-Cys peroxiredoxins (Prx) are abundant antioxidant enzymes whose
thioredoxin peroxidase activity plays an important role in protecting against oxidative stress …

Oxidative stress-mediated post-translational modifications of redox-sensitive proteins are
postulated as a key mechanism underlying age-related cellular dysfunction and disease …