JCS 2018 guideline on diagnosis and treatment of acute coronary syndrome

K Kimura, T Kimura, M Ishihara, Y Nakagawa… - Circulation …, 2019 - jstage.jst.go.jp
Acute coronary syndromes (ACS) are a comprehensive disease concept characterized by
acute myocardial ischemia caused by disruption of coronary artery plaque and consequent …

Targeting mitochondria for cardiovascular disorders: therapeutic potential and obstacles

M Bonora, MR Wieckowski, DA Sinclair… - Nature Reviews …, 2019 - nature.com
A large body of evidence indicates that mitochondrial dysfunction has a major role in the
pathogenesis of multiple cardiovascular disorders. Over the past 2 decades, extraordinary …

Myocardial reperfusion injury

DM Yellon, DJ Hausenloy - New England Journal of Medicine, 2007 - Mass Medical Soc
Lethal reperfusion injury is a paradoxical type of myocardial injury caused by the restoration
of coronary blood flow after an ischemic episode. This review focuses on the mechanisms of …

Pathogenesis of myocardial ischemia-reperfusion injury and rationale for therapy

AT Turer, JA Hill - The American journal of cardiology, 2010 - Elsevier
Since the initial description of the phenomenon by Jennings et al 50 years ago, our
understanding of the underlying mechanisms of reperfusion injury has grown significantly …

Pathophysiology of myocardial reperfusion injury: preconditioning, postconditioning, and translational aspects of protective measures

S Sanada, I Komuro, M Kitakaze - American Journal of …, 2011 - journals.physiology.org
Heart diseases due to myocardial ischemia, such as myocardial infarction or ischemic heart
failure, are major causes of death in developed countries, and their number is unfortunately …

A review of myocardial ischaemia/reperfusion injury: pathophysiology, experimental models, biomarkers, genetics and pharmacological treatment

M Gunata, H Parlakpinar - Cell biochemistry and function, 2021 - Wiley Online Library
Cardiovascular diseases are known to be the most fatal diseases worldwide.
Ischaemia/reperfusion (I/R) injury is at the centre of the pathology of the most common …

Microvascular obstruction and the no-reflow phenomenon after percutaneous coronary intervention

R Jaffe, T Charron, G Puley, A Dick, BH Strauss - Circulation, 2008 - Am Heart Assoc
3152 the number of angiographic frames required for the contrast medium to reach
standardized distal landmarks of the coronary tree, and the myocardial blush grade is a …

Human atrial natriuretic peptide and nicorandil as adjuncts to reperfusion treatment for acute myocardial infarction (J-WIND): two randomised trials

M Kitakaze, M Asakura, J Kim, Y Shintani, H Asanuma… - The Lancet, 2007 - thelancet.com
Background Patients who have acute myocardial infarction remain at major risk of
cardiovascular events. We aimed to assess the effects of either human atrial natriuretic …

No-reflow phenomenon and prognosis in patients with acute myocardial infarction

H Ito - Nature clinical practice Cardiovascular medicine, 2006 - nature.com
The rapid restoration of coronary flow to the jeopardized myocardium has become an
essential part of therapy after acute myocardial infarction. Despite an open infarct-related …

Reperfusion injury, microvascular dysfunction, and cardioprotection: the “dark side” of reperfusion

A Prasad, GW Stone, DR Holmes, B Gersh - Circulation, 2009 - Am Heart Assoc
One explanation for the failure to translate cardioprotection into clinical practice is that RI
does not occur in humans. However, it would be unusual for a biological phenomenon to be …