[HTML][HTML] The PANcreatic Disease ReseArch (PANDoRA) consortium: ten years' experience of association studies to understand the genetic architecture of pancreatic …

D Campa, M Gentiluomo, A Stein, MN Aoki… - Critical Reviews in …, 2023 - Elsevier
Pancreatic cancer has an incidence that almost matches its mortality. Only a small number of
risk factors and 33 susceptibility loci have been identified. so Moreover, the relative rarity of …

The long non-coding RNA ANRIL in cancers

A Sanchez, J Lhuillier, G Grosjean, L Ayadi, S Maenner - Cancers, 2023 - mdpi.com
Simple Summary The human genome produces various types of RNA molecules. A
significant portion of these are long non-coding RNAs (lncRNAs) exceeding 200 nts without …

[HTML][HTML] Genetic and non-genetic risk factors for early-onset pancreatic cancer

Y Nodari, M Gentiluomo… - Digestive and Liver …, 2023 - Elsevier
Background Early-onset pancreatic cancer (EOPC) represents 5–10% of all pancreatic
ductal adenocarcinoma (PDAC) cases, and the etiology of this form is poorly understood. It …

Interactive effects of CDKN2B‐AS1 gene polymorphism and habitual risk factors on oral cancer

JC Yeh, YT Chen, YE Chou, SC Su… - Journal of cellular …, 2023 - Wiley Online Library
Oral squamous cell carcinoma (OSCC) is a common malignant disease associated with a
high mortality rate and heterogeneous disease aetiology. Cyclin dependent kinase inhibitor …

Polymorphic variants involved in methylation regulation: a strategy to discover risk loci for pancreatic ductal adenocarcinoma

C Corradi, G Lencioni, M Gentiluomo, A Felici… - Journal of medical …, 2023 - jmg.bmj.com
Introduction Only a small number of risk factors for pancreatic ductal adenocarcinoma
(PDAC) has been established. Several studies identified a role of epigenetics and of …

The intergenic type LncRNA (LINC RNA) faces in cancer with in silico scope and a directed lens to LINC00511: a step toward ncRNA precision

S Eldash, EF Sanad, D Nada, NM Hamdy - Non-coding RNA, 2023 - mdpi.com
Background: Long intergenic non-coding RNA, is one type of lncRNA, exerting various
cellular activities, as does ncRNA, including the regulation of gene expression and …

Role of pancreatic ductal adenocarcinoma risk factors in intraductal papillary mucinous neoplasm progression

M Gentiluomo, C Corradi, PG Arcidiacono… - Frontiers in …, 2023 - frontiersin.org
Introduction Pancreatic ductal adenocarcinoma (PDAC) is lethal due to its late diagnosis
and lack of successful treatments. A possible strategy to reduce its death burden is …

[HTML][HTML] Analysis of exposome and genetic variability suggests stress as a major contributor for development of pancreatic ductal adenocarcinoma

G Peduzzi, A Felici, R Pellungrini, F Giorgolo… - Digestive and Liver …, 2024 - Elsevier
Background The current knowledge on pancreatic ductal adenocarcinoma (PDAC) risk
factors is limited and no study has comprehensively tested the exposome in combination …

Long or short? Telomere length and pancreatic cancer and its precursor lesions, a narrative review

D Campa, A Felici, C Corradi, G Peduzzi… - …, 2023 - academic.oup.com
Pancreatic ductal adenocarcinoma (PDAC) is the most common and lethal form of
pancreatic cancer, with a survival approaching only 11% at five years after diagnosis. In the …

Explainable machine learning identifies a polygenic risk score as a key predictor of pancreatic cancer risk in the UK Biobank

G Peduzzi, A Felici, R Pellungrini, D Campa - Digestive and Liver Disease, 2024 - Elsevier
Background Predicting the risk of developing pancreatic ductal adenocarcinoma (PDAC) is
of paramount importance, given its high mortality rate. Current PDAC risk prediction models …