Treatment of the neuronal ceroid lipofuscinoses, also known as Batten disease, is at the start
of a new era because of diagnostic and therapeutic advances relevant to this group of …

Autophagy is a catabolic process with an essential function in the maintenance of cellular
and tissue homeostasis. It is primarily recognised for its role in the degradation of …

Batten disease, one of the most devastating types of neurodegenerative lysosomal storage
disorders, is caused by mutations in CLN3. Here, we show that CLN3 is a vesicular …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Lysosomes are cell organelles that degrade macromolecules to recycle their components. If
lysosomal degradative function is impaired, eg, due to mutations in lysosomal enzymes or …

The lysosome plays a pivotal role between catabolic and anabolic processes as the nexus
for signalling pathways responsive to a variety of factors, such as growth, nutrient …

Calcium (Ca2+) signaling is an essential process in all cells that is maintained by a plethora
of channels, pumps, transporters, receptors, and intracellular Ca2+ sequestering stores …

This review discusses how lipophagy and cytosolic lipolysis degrade cellular lipids, as well
as how these pathway ys communicate, how they affect lipid metabolism and energy …

Abstract Neuronal Ceroid Lipofuscinoses (NCLs), commonly known as Batten disease,
constitute a group of the most prevalent neurodegenerative lysosomal storage disorders …

Abstract Intracellular calcium ([Ca 2+] i) has been reported to play an important role in
autophagy, apoptosis and necrosis, however, a little is known about its impact in …