Recent advances in ligand-enabled palladium-catalyzed divergent synthesis
Y Wang, J Feng, E Li, Z Jia, TP Loh - Organic & Biomolecular …, 2023 - pubs.rsc.org
Developing efficient and straightforward strategies to rapidly construct structurally distinct
and diverse organic molecules is one of the most fundamental tasks in organic synthesis …
and diverse organic molecules is one of the most fundamental tasks in organic synthesis …
Chiral Phosphine–Phosphite Ligands in Asymmetric Gold Catalysis: Highly Enantioselective Synthesis of Furo[3,4‐d]‐Tetrahydropyridazine Derivatives through [3+3] …
Q Du, JM Neudörfl, HG Schmalz - Chemistry–A European …, 2018 - Wiley Online Library
The AuI‐catalyzed reaction of 2‐(1‐alkynyl)‐2‐alken‐1‐ones with azomethine imines regio‐
and diastereoselectively affords furo [3, 4‐d] tetrahydropyridazines in a tandem cyclization …
and diastereoselectively affords furo [3, 4‐d] tetrahydropyridazines in a tandem cyclization …
[HTML][HTML] 3-nitroimidazo [1, 2-b] pyridazine as a novel scaffold for antiparasitics with sub-nanomolar anti-Giardia lamblia activity
Y Zheng, J Müller, S Kunz, M Siderius, L Maes… - International Journal for …, 2022 - Elsevier
As there is a continuous need for novel anti-infectives, the present study aimed to fuse two
modes of action into a novel 3-nitroimidazo [1, 2-b] pyridazine scaffold to improve …
modes of action into a novel 3-nitroimidazo [1, 2-b] pyridazine scaffold to improve …
Pyrimidine‐Triazolopyrimidine and Pyrimidine‐Pyridine Hybrids as Potential Acetylcholinesterase Inhibitors for Alzheimer's Disease
Acetylcholinesterase (AChE) is a critical enzyme, in Alzheimer's disease (AD) progression
and hence has been subjected to intense drug discovery programme. Here, we report …
and hence has been subjected to intense drug discovery programme. Here, we report …
Design, Synthesis, and Biological Evaluation of Novel Indanone Derivatives as Cholinesterase Inhibitors for Potential Use in Alzheimer's Disease
A Etemadi, S Hemmati… - Chemistry & …, 2023 - Wiley Online Library
Indanone derivatives containing meta/para‐substituted aminopropoxy benzyl/benzylidene
moieties were designed based on the structures of donepezil and ebselen analogs as the …
moieties were designed based on the structures of donepezil and ebselen analogs as the …
Cu-mediated synthesis of differentially substituted diazepines as AChE inhibitors; validation through molecular docking and Lipinski's filter to develop novel anti …
A highly efficient Cu-mediated route for the synthesis of fused [1, 2, 3] triazolo [1, 4]
diazepines has been developed by azidation-cyclization of 2-bromo-N-propargylamines in a …
diazepines has been developed by azidation-cyclization of 2-bromo-N-propargylamines in a …
Efficacy of phenyl quinoline phenol derivatives as COX-2 inhibitors; an approach to emergent the small molecules as the anti-inflammatory and analgesic therapeutics
A Manikandan, S Ravichandran… - …, 2017 - Springer
(4-phenylquinoline-2-yl) phenol derivatives (4a-l) with COX-2 enzyme inhibition, analgesic,
anti-inflammatory and antipyretic potentials were executed and reported. From the in vitro …
anti-inflammatory and antipyretic potentials were executed and reported. From the in vitro …
Imidazopyridazine acetylcholinesterase inhibitors display potent anti-proliferative effects in the human neuroblastoma cell-line, IMR-32
Imidazo [1, 2-b] pyridazine compounds are a new class of promising lead molecules to
which we have incorporated polar nitro and amino moieties to increase the scope of their …
which we have incorporated polar nitro and amino moieties to increase the scope of their …
Virtual screening of molecular databases for potential inhibitors of the NSP16/NSP10 methyltransferase from SARS-CoV-2
JPA Gomes, L de Oliveira Rocha, CEY Leal… - Journal of Molecular …, 2022 - Elsevier
COVID-19 is a disease caused by the SARS-CoV-2 virus and represents one of the greatest
health problems that humanity faces at the moment. Therefore, efforts have been made with …
health problems that humanity faces at the moment. Therefore, efforts have been made with …
Palladium‐Catalyzed Regioselective C− H Heteroarylation of Pyridotriazoles
An efficient and regioselective palladium‐catalyzed C− H heteroarylation of [1, 2, 3] triazolo
[1, 5‐a] pyridines with benzo [b] thiophenes and benzothiazoles is described. A series of C …
[1, 5‐a] pyridines with benzo [b] thiophenes and benzothiazoles is described. A series of C …