Cell motility is essential for life and development. Unfortunately, cell migration is also linked
to several pathological processes, such as cancer metastasis. Cells' ability to migrate relies …

During cell growth and motility in crowded tissues or interstitial spaces, cells must integrate
multiple physical and biochemical environmental inputs. After a number of recent studies …

Chromatin, which consists of DNA and associated proteins, contains genetic information and
is a mechanical component of the nucleus. Heterochromatic histone methylation controls …

Nuclear lamins are type‐V intermediate filaments that are involved in many nuclear
processes. In mammals, A‐and B‐type lamins assemble into separate physical meshwork …

Mechanotherapy is proposed as a new option for cancer treatment. Increasing evidence
suggests that characteristic differences are present in the nuclear mechanics and …

It is increasingly appreciated that the cell nucleus is not only a home for DNA but also a
complex material that resists physical deformations and dynamically responds to external …

Nuclear blebs are herniations of the nucleus that occur in diseased nuclei that cause
nuclear rupture leading to cellular dysfunction. Chromatin and lamins are two of the major …

Intro Force measurements of the nucleus, the strongest organelle, have propelled the field of
mechanobiology to understand the basic mechanical components of the nucleus and how …

The nuclear lamina (NL) plays various roles and participates in nuclear integrity, chromatin
organization, and transcriptional regulation. Lamin proteins, the main components of the NL …

The stiffness of cells and of their nuclei is a biomarker of several pathological conditions.
Current measurement methods rely on invasive physical probes that yield one or two …