Reduction of restricted repetitive behavior by environmental enrichment: potential neurobiological mechanisms

AL Farmer, MH Lewis - Neuroscience & Biobehavioral Reviews, 2023 - Elsevier
Restricted repetitive behaviors (RRB) are one of two diagnostic criteria for autism spectrum
disorder and common in other neurodevelopmental and psychiatric disorders. The term …

The cortico-striatal circuitry in autism-spectrum disorders: a balancing act

JJ Soghomonian - Frontiers in Cellular Neuroscience, 2024 - frontiersin.org
The basal ganglia are major targets of cortical inputs and, in turn, modulate cortical function
via their projections to the motor and prefrontal cortices. The role of the basal ganglia in …

Environmental enrichment improves metabolic and behavioral health in the BTBR mouse model of autism

NJ Queen, AA Boardman, RS Patel, JJ Siu, X Mo… - …, 2020 - Elsevier
Abstract BTBR T+ Itpr3tf/J (BTBR) mice are an Autism Spectrum Disorder (ASD)-like model
that exhibit behavioral and physiological deficits similar to those observed in patients with …

[HTML][HTML] Serotonin 6 receptor blockade reduces repetitive behavior in the BTBR mouse model of autism spectrum disorder

DA Amodeo, B Oliver, A Pahua, K Hitchcock… - Pharmacology …, 2021 - Elsevier
Autism spectrum disorder (ASD) is characterized by the expression of restricted repetitive
behaviors (RRBs) and impairments in social recognition and communication. Previous …

Environmental enrichment reduces restricted repetitive behavior by altering gray matter microstructure

AL Farmer, M Febo, BJ Wilkes, MH Lewis - Plos one, 2024 - journals.plos.org
Restricted, repetitive behaviors are common symptoms in neurodevelopmental disorders
including autism spectrum disorder. Despite being associated with poor developmental …

Environmental interventions reduced repetitive behavior in a mouse model

AR Bechard, S McElderry - Physiology & Behavior, 2024 - Elsevier
Repetitive motor behaviors are associated with several neurodevelopmental disorders
including autism spectrum disorder. Non-invasive environmental interventions that can …

Reduction of repetitive behavior by co-administration of adenosine receptor agonists in C58 mice

MH Lewis, H Rajpal, AM Muehlmann - Pharmacology Biochemistry and …, 2019 - Elsevier
Repetitive behaviors are diagnostic for autism spectrum disorder (ASD) and commonly
observed in other neurodevelopmental disorders. Currently, there are no effective …

[HTML][HTML] Environmental Enrichment Attenuates Repetitive Behavior and Alters the Functional Connectivity of Pain and Sensory Pathways in C58 Mice

AL Farmer, M Febo, BJ Wilkes, MH Lewis - Cells, 2024 - mdpi.com
Restricted repetitive behaviors (RRB) encompass a variety of inflexible behaviors, which are
diagnostic for autism spectrum disorder (ASD). Despite being requisite diagnostic criteria …

Pharmacological targeting of striatal indirect pathway neurons improves subthalamic nucleus dysfunction and reduces repetitive behaviors in C58 mice

AM Muehlmann, S Maletz, MA King… - Behavioural brain research, 2020 - Elsevier
Repetitive behaviors (eg, stereotypic movements, compulsions, rituals) are common features
of a number of neurodevelopmental disorders. Clinical and animal model studies point to …

Early exposure to a methyl donor supplemented diet and the development of repetitive motor behavior in a mouse model

AM Muehlmann, N Bliznyuk, I Duerr… - Developmental …, 2020 - Wiley Online Library
Motor behaviors that are repetitive and exhibit little variability in form are common in
neurodevelopmental disorders (eg, autism spectrum disorder). C58 mice exhibit persistent …