The protein kinase ataxia telangiectasia mutated (ATM) is a master regulator of double-
strand DNA break (DSB) signalling and stress responses. For three decades, ATM has been …

Definition of the disease Ataxia telangiectasia (AT) is an autosomal recessive disorder
primarily characterized by cerebellar degeneration, telangiectasia, immunodeficiency …

Neuronal communication crucially relies on exocytosis of neurotransmitters from synaptic
vesicles (SVs) which are clustered at synapses. To ensure reliable neurotransmitter release …

ABSTRACT ATM (ataxia telangiectasia mutated) protein is found associated with multiple
organelles including synaptic vesicles, endosomes and lysosomes, often in cooperation with …

Ataxia‐telangiectasia (A‐T) is characterized by neuronal degeneration, cancer, diabetes,
immune deficiency, and increased sensitivity to ionizing radiation. A‐T is attributed to the …

Research on the molecular pathology of genome instability disorders has advanced our
understanding of the complex mechanisms that safeguard genome stability and cellular …

Interest in the function of ataxia-telangiectasia-mutated protein (ATM) is extensively growing
as evidenced by preclinical studies that continuously link ATM with new intracellular …

ATM (ataxia-telangiectasia mutated) and ATR (ATM and Rad3-related) are large PI3 kinases
whose human mutations result in complex syndromes that include a compromised DNA …

Despite that the human autosomal recessive disease ataxia telangiectasia (AT) is a rare
pathology, interest in the function of ataxia-telangiectasia mutated protein (ATM) is …

Accumulating evidence indicates that ataxia-telangiectasia mutated kinase is critical for
maintaining cellular homeostasis and that it has both nuclear and cytoplasmic functions …