The discovery of leptin was intrinsically associated with its ability to regulate body weight.
However, the effects of leptin are more far-reaching and include profound glucose-lowering …

Irregular inflammatory responses are a major contributor to tissue dysfunction and inefficient
repair. Skin has proven to be a powerful model to study mechanisms that regulate …

Obesity is a well-recognized risk factor for severe influenza infections but the mechanisms
underlying susceptibility are poorly understood. Here, we identify that obese individuals …

The mechanisms whereby obesity differentially affects males and females are unclear.
Because macrophages are functionally the most important cells in obesity-induced …

Regulation of cellular metabolism is now recognized as a crucial mechanism for the
activation of innate and adaptive immune cells upon diverse extracellular stimuli …

Obesity is a major concern for global health care systems. Systemic low-grade inflammation
in obesity is a major risk factor for insulin resistance. Leptin is an adipokine secreted by the …

The sharp increase in infections associated with multidrug-resistant (MDR) bacterial
pathogens that have seriously compromised traditional chemotherapeutics is becoming a …

Salmonella enterica serovar Typhimurium (S. Typhimurium) is a Gram-negative bacterium
that induces cell death of macrophages as a key virulence strategy. We have previously …

Mycobacterium tuberculosis, the pathogen of tuberculosis (TB), can survive in host
macrophages and induce macrophages to M2 phenotype might result in latent MTB …

Pleckstrin homology domain leucine-rich repeat protein phosphatases (PHLPP) belong to
the protein phosphatase magnesium/manganese-dependent family of Ser/Thr …