Developing pioneering pharmacological strategies with CRISPR/Cas9 library screening to overcome cancer drug resistance
Y He, H Li, X Ju, B Gong - Biochimica et Biophysica Acta (BBA)-Reviews …, 2024 - Elsevier
Cancer drug resistance is a major obstacle to the effectiveness of chemoradiotherapy,
targeted therapy, and immunotherapy. CRISPR/Cas9 library screening has emerged as a …
targeted therapy, and immunotherapy. CRISPR/Cas9 library screening has emerged as a …
Hypoxanthine in the microenvironment can enable thiopurine resistance in acute lymphoblastic leukemia
X Wang, J Ostergaard, J Kang, G Sagong… - Frontiers in …, 2024 - pmc.ncbi.nlm.nih.gov
Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy, with relapse
being a major obstacle to successful treatment. Our understanding of the mechanisms …
being a major obstacle to successful treatment. Our understanding of the mechanisms …
Catabolism of extracellular glutathione supplies amino acids to support tumor growth
F Hecht, M Zocchi, ET Tuttle, NP Ward, B Smith… - bioRxiv, 2024 - biorxiv.org
Restricting amino acids from tumors is an emerging therapeutic strategy with significant
promise. While typically considered an intracellular antioxidant with tumor-promoting …
promise. While typically considered an intracellular antioxidant with tumor-promoting …
Osmotic Stress Influences Microtubule Drug Response Via WNK1 Kinase Signaling
A Monfort-Vengut, N Sanz-Gomez… - bioRxiv, 2024 - biorxiv.org
Ion homeostasis is critical for numerous cellular processes, and disturbances in ionic
balance underlie diverse pathological conditions, including cancer progression. Targeting …
balance underlie diverse pathological conditions, including cancer progression. Targeting …