The diagnosis of GH deficiency (GHD) in childhood is a multistep process involving clinical
history, examination with detailed auxology, biochemical testing, and pituitary imaging, with …

Both endocrine and non-endocrine cells of the pituitary gland are organized into structural
and functional networks which are formed during embryonic development but which may be …

The discoveries of novel functional adaptations of the hypothalamus and anterior pituitary
gland for physiological regulation have transformed our understanding of their interaction …

Experience-dependent plasticity of cell and tissue function is critical for survival by allowing
organisms to dynamically adjust physiological processes in response to changing or harsh …

Recent advances in tridimensional (3D) tissue imaging have considerably enriched our view
of the pituitary gland and its development. Whereas traditional histology of the pituitary …

The development of the anterior pituitary gland occurs in distinct sequential developmental
steps, leading to the formation of a complex organ containing five different cell types …

The pituitary is a master endocrine gland that developed early in vertebrate evolution and
therefore exists in all modern vertebrate classes. The last decade has transformed our view …

Plasticity of function is required for each of the anterior pituitary endocrine axes to support
alterations in the demand for hormone with physiological status and in response to …

Mammalian pituitaries exhibit a high degree of intercellular coordination; this enables them
to mount large-scale coordinated responses to various physiological stimuli. This type of …

The output of prolactin (PRL) is highly dynamic with dramatic changes in its secretion from
the anterior pituitary gland depending on prevailing physiological status. In adult female …