Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …

The L-type Cav1. 2 calcium channel is present throughout the animal kingdom and is
essential for some aspects of CNS function, cardiac and smooth muscle contractility …

The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the
blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in …

VSMC s in resistance arteries and arterioles express a diverse array of KV channels with
members of the KV 1, KV 2 and KV 7 families being particularly important. Members of the …

Potassium channels importantly contribute to the regulation of vascular smooth muscle
(VSM) contraction and growth. They are the dominant ion conductance of the VSM cell …

Arterioles in the peripheral microcirculation regulate blood flow to and within tissues and
organs, control capillary blood pressure and microvascular fluid exchange, govern …

L-type calcium currents conducted by Ca V 1.2 channels initiate excitation-contraction
coupling in cardiac and vascular smooth muscle. In the heart, the distal portion of the C …

Background: Sustained vascular smooth muscle contraction is mediated by extracellular
Ca2+ influx through L-type voltage-gated Ca2+ channels (VGCC) and RhoA/Rho …

Cremaster muscle arteriolar smooth muscle cells (SMCs) display inositol 1, 4, 5-
trisphosphate receptor-dependent Ca2+ waves that contribute to global myoplasmic Ca2+ …

Abstract Voltage-dependent Ca V 1.2 L-type Ca 2+ channels (LTCC) are the main route for
calcium entry in vascular smooth muscle cells (VSMC). Several studies have also …