Transposable elements (TEs) comprise about half of the mammalian genome. TEs often
contain sequences capable of recruiting the host transcription machinery, which they use to …

Histone side chains are post-translationally modified at multiple sites, including at Lys36 on
histone H3 (H3K36). Several enzymes from yeast and humans, including the …

Repeated DNA makes up a large fraction of a typical mammalian genome, and some
repetitive elements are able to move within the genome (transposons and retrotransposons) …

Transposable elements are mobile genetic units that exhibit broad diversity in their structure
and transposition mechanisms. Transposable elements occupy a large fraction of many …

SET domain-containing proteins belong to a group of enzymes named after a common
domain that utilizes the cofactor S-adenosyl-L-methionine (SAM) to achieve methylation of …

Academia and small business research units are poised to play an increasing role in drug
discovery, with drug repurposing as one of the major areas of activity. Here we summarize …

Preserving genome function and stability are paramount for ensuring cellular homeostasis,
an imbalance in which can promote diseases including cancer. In the presence of DNA …

Transposable elements (TEs) are present in roughly all genomes. These mobile DNA
sequences are able to invade genomes and their impact on genome evolution is substantial …

Single-molecule analyses of DNA replication have greatly advanced our understanding of
mammalian replication restart. Several proteins that are not part of the core replication …

We present a comprehensive analysis of the human methyltransferasome. Primary
sequences, predicted secondary structures, and solved crystal structures of known …