Mitotic DNA synthesis (MiDAS) is an unusual form of DNA replication that occurs during
mitosis. Initially, MiDAS was characterized as a process associated with intrinsically …

The perturbation of DNA replication, a phenomena termed “replication stress”, is a driving
force of genome instability and a hallmark of cancer cells. Among the DNA repair …

Using CRISPR-Cas9 nicking enzymes, we examined the interaction between the replication
machinery and single-strand breaks, one of the most common forms of endogenous DNA …

The BRCA2 tumour suppressor protein preserves genomic integrity via interactions with the
DNA-strand exchange RAD51 protein in homology-directed repair. The RAD51-binding TR2 …

DNA double-strand break (DSB) repair by homologous recombination is initiated by DNA
end resection, a process involving the controlled degradation of the 5′-terminated strands …

Tumor suppressor BRCA2 functions in homology-directed repair (HDR), the protection of
stalled replication forks, and the suppression of replicative gaps, but their relative …

Cells rapidly respond to replication stress actively slowing fork progression and inducing
fork reversal. How replication fork plasticity is achieved in the context of nuclear organization …

DNA replication is remarkably accurate with estimates of only a handful of mutations per
human genome per cell division cycle. Replication stress caused by DNA lesions …

The DNA replication process needs to be coordinated with other DNA metabolism
transactions and must eventually extend to the full genome, regardless of chromatin status …

Transcription-replication conflict is a major cause of replication stress that arises when
replication forks collide with the transcription machinery. Replication fork stalling at sites of …