Tumor necrosis factor alpha (TNFα) is a pro-inflammatory cytokine that triggers the
expression of inflammatory molecules, including other cytokines and cell adhesion …

People worldwide are living longer, and it is estimated that by 2050, the proportion of the
world's population over 60 years of age will nearly double. Natural lung aging is associated …

Here we describe the development of a human lung'small airway-on-a-chip'containing a
differentiated, mucociliary bronchiolar epithelium and an underlying microvascular …

Diabetic nephropathy (DN) is associated with an increased morbidity and mortality, resulting
in elevated cost for public health systems. DN is the main cause of chronic kidney disease …

The blood-brain barrier (BBB) is a dynamic, highly selective barrier primarily formed by
endothelial cells connected by tight junctions that separate the circulating blood from the …

Immunotherapy holds great promise for treating cancer. Nonetheless, T cell-based
immunotherapy of solid tumors has remained challenging, largely due to the lack of …

Inflammation is a protective response of the body potentially caused by microbial, viral, or
fungal infections, tissue damage, or even autoimmune reactions. The cardinal signs of …

Infection or sterile inflammation triggers site-specific attraction of leukocytes. Leukocyte
recruitment is a process comprising several steps orchestrated by adhesion molecules …

Objective: Tobacco cigarette smoking is one of the major leading causes of death
throughout the world. Smoking has both acute and chronic effect on haematological …

Mosunetuzumab, a T-cell dependent bispecific antibody that binds CD3 and CD20 to drive T-
cell mediated B-cell killing, is currently being tested in non-Hodgkin lymphoma. However …