Quadruplex-forming sequences are widely prevalent in human and other genomes,
including bacterial ones. These sequences are over-represented in eukaryotic telomeres …

Nucleic acids have been among the first targets for antitumor drugs and antibiotics. With the
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …

Despite having many key roles in cellular biology, directly imaging biologically important
RNAs has been hindered by a lack of fluorescent tools equivalent to the fluorescent proteins …

It has been hypothesized that G-quadruplexes can sequester the 3′ end of the telomere
and prevent it from being extended by telomerase. Here we purify and characterize stable …

The structural diversity and functional relevance of nucleic acids (NAs), mainly
deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), are indispensable for almost all …

Enzymes of the TET family are methylcytosine dioxygenases that undergo frequent
mutational or functional inactivation in human cancers. Recurrent loss-of-function mutations …

G-quadruplexes (G4s) are noncanonical nucleic acid structures involved in the regulation of
key cellular processes, such as transcription and replication. Since their discovery, G4s have …

DNA-based biosensors have been widely used for its stable chemical properties, cost-
effectiveness, and easy modification. G-quadruplex (G4) DNA has attracted growing interest …

Abstract G-quadruplex (G4) with stacked G-tetrads structure is able to bind hemin (iron (III)-
protoporphyrin IX) to form a unique type of DNAzyme/RNAzyme with peroxidase-mimicking …

Abstract G-quadruplex (G4) binders have been investigated to discover new anticancer
drugs worldwide in past decades. As these ligands are generally not highly cytotoxic, the …