There is highly credible evidence that melatonin mitigates cancer at the initiation,
progression and metastasis phases. In many cases, the molecular mechanisms …

Insomnia is a serious worldwide health threat, affecting nearly one third of the general
population. Melatonin has been reported to improve sleep efficiency and it was found that …

Brain aging is linked to certain types of neurodegenerative diseases and identifying new
therapeutic targets has become critical. Melatonin, a pineal hormone, associates with …

Psychological stress has a pervasive influence on our lives. In many cases adapting to
stress strengthens organisms, but chronic or severe stress is usually harmful. One surprising …

Melatonin is the major product secreted by the pineal gland at night and displays
multifunctional properties, including immunomodulatory functions. In this study, we …

Leydig cells synthesize and secrete testosterone, and are regulated by Sertoli cells. These
two cell types may work together to regulate testicular androgen production. Studies have …

Idiopathic pulmonary fibrosis (IPF) is characterized by the progressive loss of lung function
due to tissue scarring. A variety of pro-inflammatory and pro-fibrogenic factors including …

Central serous chorioretinopathy (CSC) is a vision‐threatening disease with no validated
treatment and unclear pathogenesis. It is characterized by dilation and leakage of choroidal …

The acute inflammatory lung injury is an important cause of death due to influenza A virus
(IAV) infection. Insulin-like growth factor 1 (IGF1) played an important role in the regulation of …

Melatonin is an endogenous indoleamine that has been shown to inhibit tumor growth in
laboratory models of prostate cancer. Prostate cancer risk has additionally been associated …